Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu-Asia Aging Study

Low‐density lipoprotein cholesterol (LDL‐C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL‐C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu‐Asia Aging Study) for whom the LDL‐C from fasting lipi...

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Veröffentlicht in:Movement disorders 2008-05, Vol.23 (7), p.1013-1018
Hauptverfasser: Huang, Xuemei, Abbott, Robert D., Petrovitch, Helen, Mailman, Richard B., Ross, G. Webster
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Sprache:eng
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Zusammenfassung:Low‐density lipoprotein cholesterol (LDL‐C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL‐C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu‐Asia Aging Study) for whom the LDL‐C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow‐up, 41 men developed PD (18.4/10,000 person‐years). Although the incidence of PD increased with decreasing LDL‐C in a dose‐dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person‐years in men with LDL‐C levels
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.22013