Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice
Background: Both partial-hepatectomy (PHx) and massive small bowel resection (SBR) are strong mitogenic signals to the remnant liver and intestine, respectively. This study tested the hypothesis that PHx was an additive signal for intestinal adaptation after massive SBR. Methods: Male mice underwent...
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| Veröffentlicht in: | The American journal of surgery 2002-04, Vol.183 (4), p.435-440 |
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| creator | Nelson, Lindsey A O’Brien, David P Kemp, Christopher J Williams, Jodi L Dunke-Jacobs, Erik Erwin, Christopher R Warner, Brad W |
| description | Background: Both partial-hepatectomy (PHx) and massive small bowel resection (SBR) are strong mitogenic signals to the remnant liver and intestine, respectively. This study tested the hypothesis that PHx was an additive signal for intestinal adaptation after massive SBR.
Methods: Male mice underwent either sham SBR or 50% proximal SBR. Mice from these two groups were then subjected to a 70% PHx or sham PHx. After 3 days, parameters of intestinal adaptation and liver regeneration were recorded in the remnant intestine and liver, respectively.
Results: Intestinal adaptation following SBR occurred normally, but was not enhanced after concomitant PHx. On the other hand, SBR impaired the regenerative ability of the liver following PHx.
Conclusions: Intestinal adaptation after SBR takes priority over liver regeneration after PHx. These data implicate a hierarchy with regard to adaptive alterations to organ loss and endorse an important role for the intestinal mucosa in the regulation of hepatic regeneration. |
| doi_str_mv | 10.1016/S0002-9610(02)00809-7 |
| format | Article |
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Methods: Male mice underwent either sham SBR or 50% proximal SBR. Mice from these two groups were then subjected to a 70% PHx or sham PHx. After 3 days, parameters of intestinal adaptation and liver regeneration were recorded in the remnant intestine and liver, respectively.
Results: Intestinal adaptation following SBR occurred normally, but was not enhanced after concomitant PHx. On the other hand, SBR impaired the regenerative ability of the liver following PHx.
Conclusions: Intestinal adaptation after SBR takes priority over liver regeneration after PHx. These data implicate a hierarchy with regard to adaptive alterations to organ loss and endorse an important role for the intestinal mucosa in the regulation of hepatic regeneration.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(02)00809-7</identifier><identifier>PMID: 11975933</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adaptation ; Adaptation, Physiological ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Antibodies ; Antigens ; Biological and medical sciences ; Blotting, Western ; Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery ; Enterectomy ; Epidermal growth factor ; Hepatectomy ; Hepatectomy - methods ; Histology ; Intensive care medicine ; Intestinal adaptation ; Intestine ; Intestine, Small - physiology ; Intestine, Small - surgery ; Laboratories ; Liver ; Liver - cytology ; Liver - pathology ; Liver - physiology ; Liver regeneration ; Liver Regeneration - physiology ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Models, Animal ; Organ Size ; Proliferating Cell Nuclear Antigen - physiology ; Regeneration ; Signal transduction ; Small bowel resection ; Small intestine</subject><ispartof>The American journal of surgery, 2002-04, Vol.183 (4), p.435-440</ispartof><rights>2002 Excerpta Medica Inc.</rights><rights>2002 INIST-CNRS</rights><rights>2002. Excerpta Medica Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-3a1092915e0556669f98ba77a212bba2f8a194651cd1c48825177bdf39f11603</citedby><cites>FETCH-LOGICAL-c419t-3a1092915e0556669f98ba77a212bba2f8a194651cd1c48825177bdf39f11603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2847453014?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13636825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11975933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nelson, Lindsey A</creatorcontrib><creatorcontrib>O’Brien, David P</creatorcontrib><creatorcontrib>Kemp, Christopher J</creatorcontrib><creatorcontrib>Williams, Jodi L</creatorcontrib><creatorcontrib>Dunke-Jacobs, Erik</creatorcontrib><creatorcontrib>Erwin, Christopher R</creatorcontrib><creatorcontrib>Warner, Brad W</creatorcontrib><title>Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Background: Both partial-hepatectomy (PHx) and massive small bowel resection (SBR) are strong mitogenic signals to the remnant liver and intestine, respectively. This study tested the hypothesis that PHx was an additive signal for intestinal adaptation after massive SBR.
Methods: Male mice underwent either sham SBR or 50% proximal SBR. Mice from these two groups were then subjected to a 70% PHx or sham PHx. After 3 days, parameters of intestinal adaptation and liver regeneration were recorded in the remnant intestine and liver, respectively.
Results: Intestinal adaptation following SBR occurred normally, but was not enhanced after concomitant PHx. On the other hand, SBR impaired the regenerative ability of the liver following PHx.
Conclusions: Intestinal adaptation after SBR takes priority over liver regeneration after PHx. These data implicate a hierarchy with regard to adaptive alterations to organ loss and endorse an important role for the intestinal mucosa in the regulation of hepatic regeneration.</description><subject>Adaptation</subject><subject>Adaptation, Physiological</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</subject><subject>Enterectomy</subject><subject>Epidermal growth factor</subject><subject>Hepatectomy</subject><subject>Hepatectomy - methods</subject><subject>Histology</subject><subject>Intensive care medicine</subject><subject>Intestinal adaptation</subject><subject>Intestine</subject><subject>Intestine, Small - physiology</subject><subject>Intestine, Small - surgery</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Liver - cytology</subject><subject>Liver - pathology</subject><subject>Liver - physiology</subject><subject>Liver regeneration</subject><subject>Liver Regeneration - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Models, Animal</subject><subject>Organ Size</subject><subject>Proliferating Cell Nuclear Antigen - physiology</subject><subject>Regeneration</subject><subject>Signal transduction</subject><subject>Small bowel resection</subject><subject>Small intestine</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1rFTEUxYNY7PPpn6AMiKKL0dxk8rUSKdoWCl3Yfchk7mDKTDIm85T-9-Z9YMGNq8slv3PIOZeQV0A_AgX56TullLVGAn1P2QdKNTWtekI2oJVpQWv-lGz-IufkeSn3dQXo-DNyDmCUMJxviLuOK5Y1RDc1Lg7ND1zcGnyTsSwpFmzW1Pg09yHi0Cwur6GCBwj9muaHg6jMbpqaPv3GaS-sLyHFJsRmDh5fkLPRTQVfnuaW3H37endx1d7cXl5ffLlpfQdmbbkDapgBgVQIKaUZje6dUo4B63vHRu3AdFKAH8B3WjMBSvXDyM0IICnfkndH2yWnn7sayc6heJwmFzHtilUgOTChKvjmH_A-7XLNXyzTneoEp7WkLRFHyudUSsbRLjnMLj9YoHZ_AHs4gN23a-s8HMDu3V-f3Hf9jMOj6tR4Bd6eAFe8m8bsog_lkeOSyxqucp-PHNbOfgXMtviA0eMQci3YDin85yt_AMWRoPE</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Nelson, Lindsey A</creator><creator>O’Brien, David P</creator><creator>Kemp, Christopher J</creator><creator>Williams, Jodi L</creator><creator>Dunke-Jacobs, Erik</creator><creator>Erwin, Christopher R</creator><creator>Warner, Brad W</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice</title><author>Nelson, Lindsey A ; O’Brien, David P ; Kemp, Christopher J ; Williams, Jodi L ; Dunke-Jacobs, Erik ; Erwin, Christopher R ; Warner, Brad W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-3a1092915e0556669f98ba77a212bba2f8a194651cd1c48825177bdf39f11603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adaptation</topic><topic>Adaptation, Physiological</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</topic><topic>Enterectomy</topic><topic>Epidermal growth factor</topic><topic>Hepatectomy</topic><topic>Hepatectomy - methods</topic><topic>Histology</topic><topic>Intensive care medicine</topic><topic>Intestinal adaptation</topic><topic>Intestine</topic><topic>Intestine, Small - physiology</topic><topic>Intestine, Small - surgery</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Liver - cytology</topic><topic>Liver - pathology</topic><topic>Liver - physiology</topic><topic>Liver regeneration</topic><topic>Liver Regeneration - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Models, Animal</topic><topic>Organ Size</topic><topic>Proliferating Cell Nuclear Antigen - physiology</topic><topic>Regeneration</topic><topic>Signal transduction</topic><topic>Small bowel resection</topic><topic>Small intestine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nelson, Lindsey A</creatorcontrib><creatorcontrib>O’Brien, David P</creatorcontrib><creatorcontrib>Kemp, Christopher J</creatorcontrib><creatorcontrib>Williams, Jodi L</creatorcontrib><creatorcontrib>Dunke-Jacobs, Erik</creatorcontrib><creatorcontrib>Erwin, Christopher R</creatorcontrib><creatorcontrib>Warner, Brad W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nelson, Lindsey A</au><au>O’Brien, David P</au><au>Kemp, Christopher J</au><au>Williams, Jodi L</au><au>Dunke-Jacobs, Erik</au><au>Erwin, Christopher R</au><au>Warner, Brad W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>183</volume><issue>4</issue><spage>435</spage><epage>440</epage><pages>435-440</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Background: Both partial-hepatectomy (PHx) and massive small bowel resection (SBR) are strong mitogenic signals to the remnant liver and intestine, respectively. This study tested the hypothesis that PHx was an additive signal for intestinal adaptation after massive SBR.
Methods: Male mice underwent either sham SBR or 50% proximal SBR. Mice from these two groups were then subjected to a 70% PHx or sham PHx. After 3 days, parameters of intestinal adaptation and liver regeneration were recorded in the remnant intestine and liver, respectively.
Results: Intestinal adaptation following SBR occurred normally, but was not enhanced after concomitant PHx. On the other hand, SBR impaired the regenerative ability of the liver following PHx.
Conclusions: Intestinal adaptation after SBR takes priority over liver regeneration after PHx. These data implicate a hierarchy with regard to adaptive alterations to organ loss and endorse an important role for the intestinal mucosa in the regulation of hepatic regeneration.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11975933</pmid><doi>10.1016/S0002-9610(02)00809-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Adaptation Adaptation, Physiological Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies Antigens Biological and medical sciences Blotting, Western Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery Enterectomy Epidermal growth factor Hepatectomy Hepatectomy - methods Histology Intensive care medicine Intestinal adaptation Intestine Intestine, Small - physiology Intestine, Small - surgery Laboratories Liver Liver - cytology Liver - pathology Liver - physiology Liver regeneration Liver Regeneration - physiology Male Medical sciences Mice Mice, Inbred ICR Models, Animal Organ Size Proliferating Cell Nuclear Antigen - physiology Regeneration Signal transduction Small bowel resection Small intestine |
| title | Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice |
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