Crystal structure of single-domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2008-06, Vol.71 (4), p.2091-2096
Hauptverfasser:	Park, Suk-Youl, Lee, Woo-Ram, Lee, Suk-Chan, Kwon, Myung-Hee, Kim, Yong-Sung, Kim, Jeong-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	3D8 scFv Amino Acid Sequence Amino Acid Substitution Antibodies, Antinuclear - chemistry Antibodies, Antinuclear - genetics Antibodies, Antinuclear - isolation & purification Antibodies, Antinuclear - metabolism Binding Sites bis-tris Cadmium - chemistry Cadmium - metabolism catalytic antibody Cobalt - chemistry Cobalt - metabolism crystal structure Crystallography, X-Ray DNA - chemistry DNA - genetics DNA - metabolism Escherichia coli - genetics Hydrolysis Immunoglobulin Fragments - chemistry Immunoglobulin Fragments - genetics Immunoglobulin Fragments - metabolism Metals, Heavy - chemistry Metals, Heavy - metabolism Models, Molecular Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sequence Analysis, DNA Transformation, Bacterial Tromethamine - analogs & derivatives Tromethamine - chemistry Tromethamine - metabolism Water - chemistry
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