A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Purpose: Recently, virotherapy has been proposed as a new therapeutic approach for ovarian cancer. Conditionally replicative adenoviruses (CRAd) may contain tumor-specific promoters that restrict virus replication to cancer cells. Mesothelin, a cell surface glycoprotein, is overexpressed in ovarian...

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Veröffentlicht in:	Clinical cancer research 2008-06, Vol.14 (11), p.3582-3588
Hauptverfasser:	Tsuruta, Yuko, Pereboeva, Larisa, Breidenbach, Martina, Rein, Daniel T, Wang, Minghui, Alvarez, Ronald D, Siegal, Gene P, Dent, Paul, Fisher, Paul B, Curiel, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenovirus E1A Proteins - genetics Animals Female Genetic Vectors GPI-Linked Proteins Humans imaging Membrane Glycoproteins - genetics mesothelin-promoter Mice Mice, SCID Oncolytic Virotherapy - methods ovarian cancer Ovarian Neoplasms - therapy Ovarian Neoplasms - virology Polymerase Chain Reaction Promoter Regions, Genetic virotherapy Xenograft Model Antitumor Assays
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