Hypoxia Causes Downregulation of Protein and RNA Synthesis in Noncontracting Mammalian Cardiomyocytes

The aim was to identify energy-consuming processes, other than contraction, downregulated during moderate hypoxia (≈5 μmol/L, 0.5% O2) and severe hypoxia (

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Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2002-04, Vol.90 (7), p.777-783
Hauptverfasser:	Casey, Tammy M, Pakay, Julian L, Guppy, Michael, Arthur, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Animals, Newborn Antifungal Agents - pharmacology Biological and medical sciences Cell Hypoxia - physiology Cell Separation Down-Regulation - physiology Energy Metabolism - drug effects Energy Metabolism - physiology Eukaryotic Initiation Factor-2 - drug effects Eukaryotic Initiation Factor-2 - metabolism Fundamental and applied biological sciences. Psychology Heart In Vitro Techniques Methacrylates Mitochondria - metabolism Myocardial Contraction - physiology Myocardium - cytology Myocardium - metabolism Oxygen - metabolism Oxygen Consumption - physiology Phosphocreatine - metabolism Phosphorylation - drug effects Potassium - metabolism Proteins - metabolism Rats Rats, Sprague-Dawley RNA - metabolism Signal Transduction - physiology Sodium - metabolism Thiazoles - pharmacology Vertebrates: cardiovascular system
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Beschreibung
Zusammenfassung:	The aim was to identify energy-consuming processes, other than contraction, downregulated during moderate hypoxia (≈5 μmol/L, 0.5% O2) and severe hypoxia (
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.res.0000015592.95986.03