Asymmetric Synthesis of Substituted Prolines from δ-Amino β-Ketoesters. Methyl (2S,5R)-(+)-5-Phenylpyrrolidine-2-carboxylate

Asymmetric Synthesis of Substituted Prolines from δ-Amino β-Ketoesters. Methyl (2S,5R)-(+)-5-Phenylpyrrolidine-2-carboxylate

Metal carbenoid chemistry is used to convert δ-amino β-ketoesters into 5-substituted 3-oxo prolines, which expands the utility of this class of polyfunctionalized chiral building blocks.

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Veröffentlicht in:Organic letters 2002-05, Vol.4 (9), p.1599-1602
Hauptverfasser: Davis, Franklin A, Fang, Tianan, Goswami, Rajesh
Format: Artikel
Sprache:eng
Schlagworte:
Cholecystokinin - antagonists & inhibitors
Indicators and Reagents
Keto Acids - chemistry
Piperidines - chemical synthesis
Piperidines - chemistry
Proline - analogs & derivatives
Stereoisomerism
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Beschreibung
Zusammenfassung:Metal carbenoid chemistry is used to convert δ-amino β-ketoesters into 5-substituted 3-oxo prolines, which expands the utility of this class of polyfunctionalized chiral building blocks.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol025831j