The aryl hydrocarbon receptor： a regulator of Th17 and Treg cell development in disease

The aryl hydrocarbon receptor （AhR） was discovered almost 30 years ago as a specific binding site for the halogenated polycyclic aromatic hydrocarbon, 2,3,7,8-tetrachlorodibenzo-p-dioxin （TCDD）, an environmental toxin （as reviewed in [1]）. Within the last decade, AhR was found to have a basic helixl...

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Veröffentlicht in:	Cell research 2008-06, Vol.18 (6), p.605-608
Hauptverfasser:	Ho, Peggy P, Steinman, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Cell Biology Cell Differentiation - drug effects Cytokines - pharmacology Encephalomyelitis, Autoimmune, Experimental - immunology Life Sciences Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mice Polychlorinated Dibenzodioxins - metabolism Receptors, Aryl Hydrocarbon - immunology research-highlight T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Zebrafish 芳基碳氢化合物
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Beschreibung
Zusammenfassung:	The aryl hydrocarbon receptor （AhR） was discovered almost 30 years ago as a specific binding site for the halogenated polycyclic aromatic hydrocarbon, 2,3,7,8-tetrachlorodibenzo-p-dioxin （TCDD）, an environmental toxin （as reviewed in [1]）. Within the last decade, AhR was found to have a basic helixloop-helix and function as a ligand-activated transcription factor.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2008.63