Flow cytometry analysis of platelet cyclooxygenase‐2 expression: induction of platelet cyclooxygenase‐2 in patients undergoing coronary artery bypass grafting

There are conflicting reports about the expression of cyclooxygenase (COX)‐2 in human platelets. The present study describes a flow cytometric method for the measurement of platelet COX. Both COX‐1 and COX‐2 were shown to be expressed in platelets from patients undergoing a coronary artery bypass gr...

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Veröffentlicht in:British journal of haematology 2002-05, Vol.117 (2), p.424-426
Hauptverfasser: Weber, Artur‐Aron, Przytulski, Boris, Schumacher, Marc, Zimmermann, Norbert, Gams, Emmeran, Hohlfeld, Thomas, Schrör, Karsten
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Sprache:eng
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Zusammenfassung:There are conflicting reports about the expression of cyclooxygenase (COX)‐2 in human platelets. The present study describes a flow cytometric method for the measurement of platelet COX. Both COX‐1 and COX‐2 were shown to be expressed in platelets from patients undergoing a coronary artery bypass graft. There was a significant increase in COX‐2 expression at day 5 as compared with pre‐surgery values (mean fluorescence 12·31 ± 0·88 versus 9·15 ± 0·88; means ± SEM, n = 7, P  0·05).
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2002.03423.x