Flow cytometry analysis of platelet cyclooxygenase‐2 expression: induction of platelet cyclooxygenase‐2 in patients undergoing coronary artery bypass grafting
There are conflicting reports about the expression of cyclooxygenase (COX)‐2 in human platelets. The present study describes a flow cytometric method for the measurement of platelet COX. Both COX‐1 and COX‐2 were shown to be expressed in platelets from patients undergoing a coronary artery bypass gr...
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Veröffentlicht in: | British journal of haematology 2002-05, Vol.117 (2), p.424-426 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | There are conflicting reports about the expression of cyclooxygenase (COX)‐2 in human platelets. The present study describes a flow cytometric method for the measurement of platelet COX. Both COX‐1 and COX‐2 were shown to be expressed in platelets from patients undergoing a coronary artery bypass graft. There was a significant increase in COX‐2 expression at day 5 as compared with pre‐surgery values (mean fluorescence 12·31 ± 0·88 versus 9·15 ± 0·88; means ± SEM, n = 7, P 0·05). |
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ISSN: | 0007-1048 1365-2141 |
DOI: | 10.1046/j.1365-2141.2002.03423.x |