The Tau H1 Haplotype is associated with Parkinson's disease in the Norwegian population

We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio=5.52; 95% confidence interval:...

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Veröffentlicht in:	Neuroscience letters 2002-04, Vol.322 (2), p.83-86
Hauptverfasser:	Farrer, Matt, Skipper, Lisa, Berg, Marianne, Bisceglio, Gina, Hanson, Melissa, Hardy, John, Adam, Amanda, Gwinn-Hardy, Katrina, Aasly, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Case-control study Confidence Intervals Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Epidemiology Female Genetics Genotype Haplotypes - genetics Humans Male Medical sciences Middle Aged Neurology Norway - epidemiology Odds Ratio Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Tau tau Proteins - genetics
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Zusammenfassung:	We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio=5.52; 95% confidence interval: 2.64–11.10; P=2.17×10 −6). Findings provide evidence that tau participates in the PD pathogenic process and demonstrate the value of isolated populations in mapping complex traits.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/S0304-3940(02)00106-4