hNT neurons express an immunosuppressive protein that blocks T-lymphocyte proliferation and interleukin-2 production

Ntera2/D1 cells had an A1 B8 Bw6 Cw7 DR3 DR52 major histocompatibility complex (MHC) genotype. Its neuronal derivative, hNT neurons, expressed A1 B8 Bw6 MHC class I molecules, but did not activate, and its hNT supernatant suppressed allogeneic mixed lymphocyte cultures (MLC) >98% ( p87% ( p99% (...

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Veröffentlicht in:	Journal of neuroimmunology 2002-04, Vol.125 (1), p.103-113
Hauptverfasser:	Gower, W.R, Sanberg, P.R, Brown, P.G, Salyani, S, Pasqual, C.J, McGrogan, M, Good, R.A, Engelman, R.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Tissue Transplantation - immunology Cell Communication - immunology Cell Division - immunology Culture Media, Conditioned Gene Expression - immunology histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics hNT protein Humans Immunosuppresion Interleukin-2 - biosynthesis ionomycin Lymphocyte Activation - immunology Neoplastic Stem Cells - cytology Neoplastic Stem Cells - immunology Neuron Neurons - cytology Neurons - immunology phorbol 12-myristate 13-acetate Protein T lymphocyte T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Cells, Cultured
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Zusammenfassung:	Ntera2/D1 cells had an A1 B8 Bw6 Cw7 DR3 DR52 major histocompatibility complex (MHC) genotype. Its neuronal derivative, hNT neurons, expressed A1 B8 Bw6 MHC class I molecules, but did not activate, and its hNT supernatant suppressed allogeneic mixed lymphocyte cultures (MLC) >98% ( p87% ( p99% ( p
ISSN:	0165-5728 1872-8421
DOI:	10.1016/S0165-5728(02)00041-3