Reproducibility of brain tissue volumes in longitudinal studies: Effects of changes in signal-to-noise ratio and scanner software

Reproducibility of brain tissue volumes in longitudinal studies: Effects of changes in signal-to-noise ratio and scanner software

It is imperative that users of voxel-based morphometry (VBM) be aware of its reproducibility and the factors which influence results. We assessed the reproducibility of a VBM software package (SPM5) in measuring gray matter (GM) and white matter (WM) volumes from at least two consecutive 3D T1-weigh...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2008-06, Vol.41 (2), p.371-379
Hauptverfasser: Shuter, Borys, Yeh, Ing Berne, Graham, Steven, Au, Chris, Wang, Shih-Chang
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age
Brain - anatomy & histology
Brain segmentation
Female
Humans
Image Interpretation, Computer-Assisted - instrumentation
Image Interpretation, Computer-Assisted - methods
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Noise
Personal computers
Preventive maintenance
Reproducibility
Reproducibility of Results
Scanners
Signal-to-noise ratio
Software
SPM5
Statistical probability mapping
Studies
Voxel-based morphometry (VBM)
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Zusammenfassung:It is imperative that users of voxel-based morphometry (VBM) be aware of its reproducibility and the factors which influence results. We assessed the reproducibility of a VBM software package (SPM5) in measuring gray matter (GM) and white matter (WM) volumes from at least two consecutive 3D T1-weighted studies in 64 subjects. Factors investigated were the inter-study interval (ISI: 2.2 h to 124 days), signal-to-noise ratio (SNR: number of image averages (NA)=1 or 2), scanner software version and idle time. SNR was measured by direct estimation of tissue noise (SNRTN) and mean intensity in noise-only voxels (SNRNO). After the scanner software upgrade, voxel intensity increased 5-fold and WM mean SNRTN by 24% (p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.02.003