Regulation of flow and wall shear stress in arteriolar networks of the hamster cheek pouch
Departments of 1 Anesthesiology and 2 Biomedical Engineering, and 3 Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 Our purpose was to define arteriolar network hemodynamics during moderate increases in interstitial adenosine...
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Veröffentlicht in: | Journal of applied physiology (1985) 2002-05, Vol.92 (5), p.2080-2088 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Departments of 1 Anesthesiology and
2 Biomedical Engineering, and 3 Center
for Cardiovascular Research, University of Rochester School of Medicine
and Dentistry, Rochester, New York 14642
Our purpose was to define
arteriolar network hemodynamics during moderate increases in
interstitial adenosine or nitric oxide in the hamster
( n = 34, pentobarbital sodium 70 mg/kg) cheek pouch tissue. The network consists of a feed arteriole (~12-µm diameter, ~800-µm length) with three to six branches. Observations of
diameter, red blood cell flux, and velocity were obtained at the feed
before the branch and within the branch. A comparison of
baseline with suffused adenosine or sodium nitroprusside (SNP)
10 9 to 10 5 M showed the following. First,
diameter change was heterogeneous by agonist, did not reflect the
expected dilatory response, and was related to location within the
network. With adenosine, upstream branch points constricted and those
downstream dilated, even at 10 5 M. With SNP, upstream
branch points dilated, whereas those downstream constricted. Second,
with adenosine, changes in diameter, flux, and velocity together
resulted in no change in wall shear stress until 10 5 M. Wall shear stress was not maintained at a constant level with N -nitro- L -arginine
(10 5 M), suggesting a role for flow-dependent diameter
changes with adenosine. With SNP, diameter change correlated with the
baseline (before SNP) shear stress conditions.
flow-dependent dilation; adenosine; nitric oxide |
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ISSN: | 8750-7587 1522-1601 |
DOI: | 10.1152/japplphysiol.00984.2001 |