Probing Specificity in Carbohydrate-Carbohydrate Interactions with Micelles and Langmuir Monolayers

Probing Specificity in Carbohydrate-Carbohydrate Interactions with Micelles and Langmuir Monolayers

The epimerization of a single axial hydroxy group in a carbohydrate can affect carbohydrate–carbohydrate interactions significantly. Glycolipid micelles and glycolipid‐containing Langmuir monolayers (see picture) were used to model these key interactions on the molecular level. (GM3 is the gangliosi...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-01, Vol.42 (1), p.95-98
Hauptverfasser: Santacroce, Paul V., Basu, Amit
Format: Artikel
Sprache:eng
Schlagworte:
1,2-Dipalmitoylphosphatidylcholine - chemistry
carbohydrates
Carbohydrates - chemistry
Cellobiose - chemistry
G(M3) Ganglioside - chemistry
glycolipids
Glycolipids - chemistry
Lactosylceramides - chemistry
membranes
Membranes, Artificial
Micelles
molecular recognition
Molecular Structure
noncovalent interactions
Pressure
Stereoisomerism
Surface Properties
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Zusammenfassung:The epimerization of a single axial hydroxy group in a carbohydrate can affect carbohydrate–carbohydrate interactions significantly. Glycolipid micelles and glycolipid‐containing Langmuir monolayers (see picture) were used to model these key interactions on the molecular level. (GM3 is the ganglioside sialosyl‐lactosylceramide found on the surface of melanoma cells.)
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200390063