Capsular Polysaccharide Conjugate Vaccines against Contagious Bovine Pleuropneumonia: Immune Responses and Protection in Mice

The immunogenicity of Mycoplasma mycoides subsp. mycoides small colony biotype (MmmSC) vaccines was investigated in BALB/c mice. Groups of mice were vaccinated with either (1) unconjugated capsular polysaccharide (CPS), (2) CPS covalently conjugated to ovalbumin via a carbodiimide reaction, (3) CPS...

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Veröffentlicht in:	Journal of comparative pathology 2002-02, Vol.126 (2-3), p.171-182
Hauptverfasser:	Waite, E.R., March, J.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Capsules - immunology Bacterial Vaccines - biosynthesis Bacterial Vaccines - therapeutic use Cattle Cattle Diseases Dose-Response Relationship, Immunologic Enzyme-Linked Immunosorbent Assay Immune Sera - pharmacology Immunity Immunoglobulin G - immunology Mice Mice, Inbred BALB C Mycoplasma mycoides - drug effects Mycoplasma mycoides - immunology Ovalbumin - immunology Pleuropneumonia, Contagious - immunology Pleuropneumonia, Contagious - prevention & control Polysaccharides, Bacterial - immunology Vaccines, Conjugate - biosynthesis Vaccines, Conjugate - therapeutic use
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Zusammenfassung:	The immunogenicity of Mycoplasma mycoides subsp. mycoides small colony biotype (MmmSC) vaccines was investigated in BALB/c mice. Groups of mice were vaccinated with either (1) unconjugated capsular polysaccharide (CPS), (2) CPS covalently conjugated to ovalbumin via a carbodiimide reaction, (3) CPS non-covalently bound to latex microspheres, (4) CPS non-covalently complexed with rabbit anti-CPS IgG, and (5) whole inactivated, ultrasonically disrupted (WID) MmmSC. Only mice immunized with the CPS-ovalbumin conjugate exhibited a significant (P
ISSN:	0021-9975 1532-3129
DOI:	10.1053/jcpa.2001.0540