Increased myocardial expression of osteopontin in patients with advanced heart failure

The expression of the adhesion protein osteopontin (OP) is associated with cardiac hypertrophy and is significantly increased after transition to heart failure in experimental animal models. We, therefore, hypothesized that OP could be upregulated in heart failure in humans. In the present study, we...

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Veröffentlicht in:European journal of heart failure 2002-03, Vol.4 (2), p.139-146
Hauptverfasser: Stawowy, Philipp, Blaschke, Florian, Pfautsch, Peter, Goetze, Stephan, Lippek, Frank, Wollert-Wulf, Brigitte, Fleck, Eckart, Graf, Kristof
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Sprache:eng
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Zusammenfassung:The expression of the adhesion protein osteopontin (OP) is associated with cardiac hypertrophy and is significantly increased after transition to heart failure in experimental animal models. We, therefore, hypothesized that OP could be upregulated in heart failure in humans. In the present study, we investigated the expression of OP in myocardial biopsies obtained from patients with heart failure due to dilated cardiomyopathy (mean LVEF ‐ 30.3±4.4%, mean±S.D., n ‐ 10, group A) compared to patients with a normal left‐ventricular ejection fraction (mean LVEF ‐ 61±11.2%, n ‐ 9; group B). Myocardial immunoreactivity for OP was examined using two different antibodies against OP. The expression of cardiac myocyte OP was significantly upregulated in group A in comparison to group B (P
ISSN:1388-9842
1879-0844
DOI:10.1016/S1388-9842(01)00237-9