Infectivity of Plasmodium falciparum gametocytes to Anopheles arabiensis after treatment with sulfadoxine-pyrimethamine

Sulfadoxine-pyrimethamine induces increased gametocytaemia when used for treating Plasmodium falciparum malaria. Laboratory-reared Anopheles arabiensis mosquitoes were fed with blood from patients with post-therapeutic gametocytaemia using a membrane feeder. Fourteen days later the heads and thoraxe...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 2003-11, Vol.97 (6), p.707-708
Hauptverfasser:	Govere, J.M., Durrheim, D.N., Mngomezulu, N.M., Barnes, K., Sharp, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anopheles - parasitology Anopheles arabiensis Antimalarials - pharmacology Drug Combinations gametocytes Gametogenesis infectivity Insect Vectors - parasitology malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - transmission Plasmodium falciparum Plasmodium falciparum - drug effects Pyrimethamine - pharmacology South Africa Sulfadoxine - pharmacology sulfadoxine-pyrimethamine
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Zusammenfassung:	Sulfadoxine-pyrimethamine induces increased gametocytaemia when used for treating Plasmodium falciparum malaria. Laboratory-reared Anopheles arabiensis mosquitoes were fed with blood from patients with post-therapeutic gametocytaemia using a membrane feeder. Fourteen days later the heads and thoraxes of 613 mosquitoes were negative for P. falciparum sporozoites by enzyme-linked immunosorbent assay.
ISSN:	0035-9203 1878-3503
DOI:	10.1016/S0035-9203(03)80108-6