Characterization of Long-Term Outcomes After Toupet Fundoplication: Symptoms, Medication Use, and Health Status

GOALS AND BACKGROUNDFundoplication is increasingly used for the treatment of gastroesophageal reflux disease (GERD). Few studies have tracked patient outcomes of the Toupet method for more than 1 year. Further clinical, physiologic, and patient-based outcome measures have not been well characterized...

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Veröffentlicht in:Journal of clinical gastroenterology 2002-05, Vol.34 (5), p.509-515
Hauptverfasser: Klapow, Joshua C, Wilcox, C Mel, Mallinger, Alison P, Marks, Robert, Heudebert, Gustavo R, Centor, Robert M, Lawrence, William, Richter, Joel
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Sprache:eng
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Zusammenfassung:GOALS AND BACKGROUNDFundoplication is increasingly used for the treatment of gastroesophageal reflux disease (GERD). Few studies have tracked patient outcomes of the Toupet method for more than 1 year. Further clinical, physiologic, and patient-based outcome measures have not been well characterized for this method. The current study conducts a long-term, comprehensive outcome evaluation in patients receiving Toupet fundoplication. STUDYFifty-five patients who had previously undergone fundoplication were examined. In a subset of 24 patients, esophagogastroduodenoscopy was used to assess the severity of reflux esophagitis. Manometry and ambulatory pH monitoring also were performed. RESULTSPatients were studied 2.9 (± 0.7) years after surgery. Sixty-seven percent of the sample reported heartburn, 51% reported postoperative bloating, 33% reported regurgitation, and 20% reported dysphagia. Thirty-three percent reported the use of prescription medications for GERD-related symptoms. Health status was diminished relative to population norms. Degree of GERD severity was associated with symptom reports and medication use. CONCLUSIONSAlthough fundoplication is thought to be a curative procedure, the current findings suggest that many patients take symptomatic therapies and report symptoms and diminished health status up to 2 years after the procedure. These outcomes are associated with physiologic findings. Thus, these findings suggest that symptom-free status and absence of medication use cannot be assumed for all patients after Toupet fundoplication.
ISSN:0192-0790
1539-2031
DOI:10.1097/00004836-200205000-00006