Evaluation of a new Plasmodium lactate dehydrogenase assay (OptiMAL-IT®) for the detection of malaria

The new OptiMAL-IT® rapid diagnostic test for malaria was evaluated in 271 patients in Thailand withuncomplicated malaria between June and July 2002. The sensitivity and specificity for the diagnosis of Plasmodium falciparum parasites were 88% and 92%, respectively. For species other than P. falcipa...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 2003-11, Vol.97 (6), p.672-674
Hauptverfasser:	Pattanasin, S., Proux, S., Chompasuk, D., Luwiradaj, K., Jacquier, P., Looareesuwan, S., Nosten, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Animals Antigens, Protozoan - blood Child Child, Preschool Clinical Enzyme Tests - methods Female histidine-rich protein II Humans L-Lactate Dehydrogenase - blood malaria Malaria - diagnosis Male Middle Aged Parasitemia - diagnosis Plasmodium falciparum Plasmodium lactate dehydrogenase Reagent Kits, Diagnostic Reproducibility of Results Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	The new OptiMAL-IT® rapid diagnostic test for malaria was evaluated in 271 patients in Thailand withuncomplicated malaria between June and July 2002. The sensitivity and specificity for the diagnosis of Plasmodium falciparum parasites were 88% and 92%, respectively. For species other than P. falciparum, the sensitivity was 65% and specificity was 99%. The performance of the new test decreased markedly at low levels of parasitaemia.
ISSN:	0035-9203 1878-3503
DOI:	10.1016/S0035-9203(03)80100-1