Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl- l-carnitine

The present study was designed to characterize cardiac autonomic neuropathy in streptozotocin-induced (45 mg/kg i.v.) diabetic rat by analysis of heart rate variability (HRV), and to assess, in this model, the effects of treatment with acetyl- l-carnitine (ALC). Heart rate was reduced in diabetic ra...

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Veröffentlicht in:Diabetes research and clinical practice 2002-06, Vol.56 (3), p.173-180
Hauptverfasser: Lo Giudice, Pietro, Careddu, Antonia, Magni, Giuseppina, Quagliata, Teresa, Pacifici, Licia, Carminati, Paolo
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Sprache:eng
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Zusammenfassung:The present study was designed to characterize cardiac autonomic neuropathy in streptozotocin-induced (45 mg/kg i.v.) diabetic rat by analysis of heart rate variability (HRV), and to assess, in this model, the effects of treatment with acetyl- l-carnitine (ALC). Heart rate was reduced in diabetic rats (332±22 vs. 411±35 beat per min; P
ISSN:0168-8227
1872-8227
DOI:10.1016/S0168-8227(01)00375-8