Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance

Summary Ferredoxin, Fd, is often deficient in metronidazole‐resistant strains of Trichomonas vaginalis and is thought to be necessary for drug activation. To directly test whether Fd is essential for metronidazole susceptibility, gene replacement technology has been developed for T. vaginalis. The s...

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Veröffentlicht in:Molecular microbiology 2004-01, Vol.51 (1), p.115-122
Hauptverfasser: Land, Kirkwood M., Delgadillo‐Correa, Maria G., Tachezy, Jan, Vanacova, Stepanka, Hsieh, Christine L., Sutak, Robert, Johnson, Patricia J.
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Sprache:eng
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