Aging and hypertension as factors of progressive renal failure

Aging and hypertension as factors of progressive renal failure

This study evaluated the effects of aging on renal hemodynamic, biochemical and histological parameters in spontaneously hypertensive rats. Systolic blood pressure was measured in male SHR (adult--adSHR and aged--agSHR) during four weeks, indirectly, once a week At the end of the experiment 24 h uri...

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Veröffentlicht in:Medicinski pregled 2003, Vol.56 Suppl 1, p.59-64
Hauptverfasser: Mihailović-Stanojević, Nevena, Varagić, Jasmina, Jovović, Durdica, Miloradović, Zoran, Marković-Lipkovski, Jasmina, Jerkić, Mirjana
Format: Artikel
Sprache:srp
Schlagworte:
Aging - pathology
Aging - physiology
Animals
Blood Pressure
Disease Progression
Hemodynamics
Hypertension - physiopathology
Kidney - blood supply
Kidney - pathology
Male
Rats
Rats, Inbred SHR
Renal Insufficiency - physiopathology
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Zusammenfassung:This study evaluated the effects of aging on renal hemodynamic, biochemical and histological parameters in spontaneously hypertensive rats. Systolic blood pressure was measured in male SHR (adult--adSHR and aged--agSHR) during four weeks, indirectly, once a week At the end of the experiment 24 h urine samples were collected and hemodynamic measurements were performed. Animals were sacrificed and blood samples were collected for biochemical analysis. The left kidney was histopathologically examined. Our results show that there is no difference in systolic blood pressure between adult and aged SH rats. Renal blood flow was significantly decreased (0.68+/-0.08 vs. 0.99+/-0.007 ml/min/100 g b.w.), while renal vascular resistance increased by 28.90% in aged gSH rats. Plasma creatinine (Pcr) level was decreased in agSHR compared to adSHR (p
ISSN:0025-8105