Electrospun nanofibrous structure: A novel scaffold for tissue engineering
The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L‐lactide‐co‐glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue‐engineering applications. Electrospinning i...
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| Veröffentlicht in: | Journal of biomedical materials research 2002-06, Vol.60 (4), p.613-621 |
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| container_title | Journal of biomedical materials research |
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| creator | Li, Wan-Ju Laurencin, Cato T. Caterson, Edward J. Tuan, Rocky S. Ko, Frank K. |
| description | The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L‐lactide‐co‐glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue‐engineering applications. Electrospinning is a process whereby ultra‐fine fibers are formed in a high‐voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell–matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613–621, 2002 |
| doi_str_mv | 10.1002/jbm.10167 |
| format | Article |
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A novel poly(D,L‐lactide‐co‐glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue‐engineering applications. Electrospinning is a process whereby ultra‐fine fibers are formed in a high‐voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell–matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613–621, 2002</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/jbm.10167</identifier><identifier>PMID: 11948520</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Cells, Cultured ; electrospinning ; Extracellular Matrix - chemistry ; Extracellular Matrix - metabolism ; Fibroblasts - metabolism ; Fibroblasts - ultrastructure ; Humans ; Medical sciences ; mesenchymal stem cell ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Scanning ; Nanotechnology - instrumentation ; Nanotechnology - methods ; PLGA ; scaffold ; Stem Cells - metabolism ; tissue engineering ; Tissue Engineering - instrumentation ; Tissue Engineering - methods</subject><ispartof>Journal of biomedical materials research, 2002-06, Vol.60 (4), p.613-621</ispartof><rights>Copyright © 2002 Wiley Periodicals, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 Wiley Periodicals, Inc. 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Biomed. Mater. Res</addtitle><description>The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L‐lactide‐co‐glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue‐engineering applications. Electrospinning is a process whereby ultra‐fine fibers are formed in a high‐voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell–matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613–621, 2002</description><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>electrospinning</subject><subject>Extracellular Matrix - chemistry</subject><subject>Extracellular Matrix - metabolism</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - ultrastructure</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>mesenchymal stem cell</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nanotechnology - instrumentation</subject><subject>Nanotechnology - methods</subject><subject>PLGA</subject><subject>scaffold</subject><subject>Stem Cells - metabolism</subject><subject>tissue engineering</subject><subject>Tissue Engineering - instrumentation</subject><subject>Tissue Engineering - methods</subject><issn>0021-9304</issn><issn>1097-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEQgC0EoiFw4A-gvYDEYek4fnMrVUmpUriAOFpe77hy2XiDvUvbf48hgZ4QpxlpvnnoG0KeU3hDAVbH1922JlSqB2RBwaiWSyYfkkWt0dYw4EfkSSnXAGAMo4_JEaWGa7GCBbk4G9BPeSy7OTXJpTHELo9zacqUZz_NGd82J00af-DQFO9CGIe-CWNupljKjA2mq5gQc0xXT8mj4IaCzw5xSb68P_t8et5uPq0_nJ5sWs-1VK3yQmohIHDFJJig0fU-CNb3XPVS6p471BIoNywA6zqh0QjoPdMAIkjDluTVfu4uj99nLJPdxuJxGFzCerlVVBhY8dV_QaqFUqBUBV_vQV9FlIzB7nLcunxnKdhfhm01bH8bruyLw9C522J_Tx6UVuDlAXBV2BCySz6We45JwUR90JIc77mbOODdvzfai3eXf1a3-45YJrz92-HyN1urStivH9eWnTO-0WJtL9lP8-egLg</recordid><startdate>20020615</startdate><enddate>20020615</enddate><creator>Li, Wan-Ju</creator><creator>Laurencin, Cato T.</creator><creator>Caterson, Edward J.</creator><creator>Tuan, Rocky S.</creator><creator>Ko, Frank K.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020615</creationdate><title>Electrospun nanofibrous structure: A novel scaffold for tissue engineering</title><author>Li, Wan-Ju ; Laurencin, Cato T. ; Caterson, Edward J. ; Tuan, Rocky S. ; Ko, Frank K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4867-7c568550f473609f8eadcf53dd47d668d4ae8601493f03bb58e950dc38005f693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>electrospinning</topic><topic>Extracellular Matrix - chemistry</topic><topic>Extracellular Matrix - metabolism</topic><topic>Fibroblasts - metabolism</topic><topic>Fibroblasts - ultrastructure</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>mesenchymal stem cell</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microscopy, Electron, Scanning</topic><topic>Nanotechnology - instrumentation</topic><topic>Nanotechnology - methods</topic><topic>PLGA</topic><topic>scaffold</topic><topic>Stem Cells - metabolism</topic><topic>tissue engineering</topic><topic>Tissue Engineering - instrumentation</topic><topic>Tissue Engineering - methods</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Wan-Ju</creatorcontrib><creatorcontrib>Laurencin, Cato T.</creatorcontrib><creatorcontrib>Caterson, Edward J.</creatorcontrib><creatorcontrib>Tuan, Rocky S.</creatorcontrib><creatorcontrib>Ko, Frank K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Wan-Ju</au><au>Laurencin, Cato T.</au><au>Caterson, Edward J.</au><au>Tuan, Rocky S.</au><au>Ko, Frank K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrospun nanofibrous structure: A novel scaffold for tissue engineering</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2002-06-15</date><risdate>2002</risdate><volume>60</volume><issue>4</issue><spage>613</spage><epage>621</epage><pages>613-621</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L‐lactide‐co‐glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue‐engineering applications. Electrospinning is a process whereby ultra‐fine fibers are formed in a high‐voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell–matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613–621, 2002</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11948520</pmid><doi>10.1002/jbm.10167</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biocompatible Materials - chemistry Biological and medical sciences Cells, Cultured electrospinning Extracellular Matrix - chemistry Extracellular Matrix - metabolism Fibroblasts - metabolism Fibroblasts - ultrastructure Humans Medical sciences mesenchymal stem cell Mice Mice, Inbred BALB C Microscopy, Electron, Scanning Nanotechnology - instrumentation Nanotechnology - methods PLGA scaffold Stem Cells - metabolism tissue engineering Tissue Engineering - instrumentation Tissue Engineering - methods |
| title | Electrospun nanofibrous structure: A novel scaffold for tissue engineering |
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