The human PER1 gene is inducible by interleukin-6
The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the...
Gespeichert in:
Veröffentlicht in: | Journal of molecular neuroscience 2002-02, Vol.18 (1-2), p.105-110 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 110 |
---|---|
container_issue | 1-2 |
container_start_page | 105 |
container_title | Journal of molecular neuroscience |
container_volume | 18 |
creator | Motzkus, Dirk Albrecht, Urs Maronde, Erik |
description | The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters. |
doi_str_mv | 10.1385/JMN:18:1-2:105 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71581977</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2419979991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-fba56fb394667d02ab419c45a2014cadc59e46abf3a333f614eec67fb946c49f3</originalsourceid><addsrcrecordid>eNqFkLlPwzAYxS0EolBYGVHEwJbiLz5id0NVuVQOoTJbtmPTlBwlbob-9xi1EoiF6Tv0e096D6EzwCMggl09PD6NQYwhzcaA2R46wkKyVHDJ93_tA3QcwhLjDCiIQzQAkAQIxUcI5guXLPpaN8nL9BWSd9e4pAxJ2RS9LU3lErOJx9p1les_yiblJ-jA6yq4090coreb6Xxyl86eb-8n17PUEirXqTeacW-IpJznBc60oSAtZTrDQK0uLJOOcm080YQQz4E6Z3nuTRRYKj0Zosut76prP3sX1qoug3VVpRvX9kHlwATIPP8XBEFyITMRwYs_4LLtuyaGUEIA5xnFPEKjLWS7NoTOebXqylp3GwVYfVeuYuXRU4HK4otFwfnOtTe1K37wXcfkC7x8eak</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>881662406</pqid></control><display><type>article</type><title>The human PER1 gene is inducible by interleukin-6</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Motzkus, Dirk ; Albrecht, Urs ; Maronde, Erik</creator><creatorcontrib>Motzkus, Dirk ; Albrecht, Urs ; Maronde, Erik</creatorcontrib><description>The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1385/JMN:18:1-2:105</identifier><identifier>PMID: 11931340</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Cell Cycle Proteins ; Circadian Rhythm - drug effects ; Circadian Rhythm - genetics ; Cyclic AMP Response Element-Binding Protein - drug effects ; Cyclic AMP Response Element-Binding Protein - metabolism ; Cyclic AMP-Dependent Protein Kinases - drug effects ; Cyclic AMP-Dependent Protein Kinases - metabolism ; Dichlororibofuranosylbenzimidazole - analogs & derivatives ; Dichlororibofuranosylbenzimidazole - pharmacology ; Dose-Response Relationship, Drug ; Eukaryotic Cells - drug effects ; Eukaryotic Cells - metabolism ; Feedback - drug effects ; Feedback - physiology ; Genes ; Genes, Reporter - drug effects ; Genes, Reporter - genetics ; Homeostasis - drug effects ; Homeostasis - genetics ; Humans ; Interleukin-6 - metabolism ; Interleukin-6 - pharmacology ; Mitogen-Activated Protein Kinases - drug effects ; Mitogen-Activated Protein Kinases - metabolism ; Nuclear Proteins - genetics ; Period Circadian Proteins ; Promoter Regions, Genetic - drug effects ; Promoter Regions, Genetic - genetics ; Signal Transduction - drug effects ; Signal Transduction - genetics ; Sleep - drug effects ; Sleep - genetics ; Thionucleotides - pharmacology ; Tumor Cells, Cultured</subject><ispartof>Journal of molecular neuroscience, 2002-02, Vol.18 (1-2), p.105-110</ispartof><rights>Humana Press Inc. 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-fba56fb394667d02ab419c45a2014cadc59e46abf3a333f614eec67fb946c49f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11931340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motzkus, Dirk</creatorcontrib><creatorcontrib>Albrecht, Urs</creatorcontrib><creatorcontrib>Maronde, Erik</creatorcontrib><title>The human PER1 gene is inducible by interleukin-6</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><description>The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters.</description><subject>Cell Cycle Proteins</subject><subject>Circadian Rhythm - drug effects</subject><subject>Circadian Rhythm - genetics</subject><subject>Cyclic AMP Response Element-Binding Protein - drug effects</subject><subject>Cyclic AMP Response Element-Binding Protein - metabolism</subject><subject>Cyclic AMP-Dependent Protein Kinases - drug effects</subject><subject>Cyclic AMP-Dependent Protein Kinases - metabolism</subject><subject>Dichlororibofuranosylbenzimidazole - analogs & derivatives</subject><subject>Dichlororibofuranosylbenzimidazole - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eukaryotic Cells - drug effects</subject><subject>Eukaryotic Cells - metabolism</subject><subject>Feedback - drug effects</subject><subject>Feedback - physiology</subject><subject>Genes</subject><subject>Genes, Reporter - drug effects</subject><subject>Genes, Reporter - genetics</subject><subject>Homeostasis - drug effects</subject><subject>Homeostasis - genetics</subject><subject>Humans</subject><subject>Interleukin-6 - metabolism</subject><subject>Interleukin-6 - pharmacology</subject><subject>Mitogen-Activated Protein Kinases - drug effects</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Nuclear Proteins - genetics</subject><subject>Period Circadian Proteins</subject><subject>Promoter Regions, Genetic - drug effects</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - genetics</subject><subject>Sleep - drug effects</subject><subject>Sleep - genetics</subject><subject>Thionucleotides - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0895-8696</issn><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkLlPwzAYxS0EolBYGVHEwJbiLz5id0NVuVQOoTJbtmPTlBwlbob-9xi1EoiF6Tv0e096D6EzwCMggl09PD6NQYwhzcaA2R46wkKyVHDJ93_tA3QcwhLjDCiIQzQAkAQIxUcI5guXLPpaN8nL9BWSd9e4pAxJ2RS9LU3lErOJx9p1les_yiblJ-jA6yq4090coreb6Xxyl86eb-8n17PUEirXqTeacW-IpJznBc60oSAtZTrDQK0uLJOOcm080YQQz4E6Z3nuTRRYKj0Zosut76prP3sX1qoug3VVpRvX9kHlwATIPP8XBEFyITMRwYs_4LLtuyaGUEIA5xnFPEKjLWS7NoTOebXqylp3GwVYfVeuYuXRU4HK4otFwfnOtTe1K37wXcfkC7x8eak</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Motzkus, Dirk</creator><creator>Albrecht, Urs</creator><creator>Maronde, Erik</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>The human PER1 gene is inducible by interleukin-6</title><author>Motzkus, Dirk ; Albrecht, Urs ; Maronde, Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-fba56fb394667d02ab419c45a2014cadc59e46abf3a333f614eec67fb946c49f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Cell Cycle Proteins</topic><topic>Circadian Rhythm - drug effects</topic><topic>Circadian Rhythm - genetics</topic><topic>Cyclic AMP Response Element-Binding Protein - drug effects</topic><topic>Cyclic AMP Response Element-Binding Protein - metabolism</topic><topic>Cyclic AMP-Dependent Protein Kinases - drug effects</topic><topic>Cyclic AMP-Dependent Protein Kinases - metabolism</topic><topic>Dichlororibofuranosylbenzimidazole - analogs & derivatives</topic><topic>Dichlororibofuranosylbenzimidazole - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eukaryotic Cells - drug effects</topic><topic>Eukaryotic Cells - metabolism</topic><topic>Feedback - drug effects</topic><topic>Feedback - physiology</topic><topic>Genes</topic><topic>Genes, Reporter - drug effects</topic><topic>Genes, Reporter - genetics</topic><topic>Homeostasis - drug effects</topic><topic>Homeostasis - genetics</topic><topic>Humans</topic><topic>Interleukin-6 - metabolism</topic><topic>Interleukin-6 - pharmacology</topic><topic>Mitogen-Activated Protein Kinases - drug effects</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Nuclear Proteins - genetics</topic><topic>Period Circadian Proteins</topic><topic>Promoter Regions, Genetic - drug effects</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - genetics</topic><topic>Sleep - drug effects</topic><topic>Sleep - genetics</topic><topic>Thionucleotides - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motzkus, Dirk</creatorcontrib><creatorcontrib>Albrecht, Urs</creatorcontrib><creatorcontrib>Maronde, Erik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motzkus, Dirk</au><au>Albrecht, Urs</au><au>Maronde, Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The human PER1 gene is inducible by interleukin-6</atitle><jtitle>Journal of molecular neuroscience</jtitle><addtitle>J Mol Neurosci</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>18</volume><issue>1-2</issue><spage>105</spage><epage>110</epage><pages>105-110</pages><issn>0895-8696</issn><eissn>0895-8696</eissn><eissn>1559-1166</eissn><abstract>The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>11931340</pmid><doi>10.1385/JMN:18:1-2:105</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0895-8696 |
ispartof | Journal of molecular neuroscience, 2002-02, Vol.18 (1-2), p.105-110 |
issn | 0895-8696 0895-8696 1559-1166 |
language | eng |
recordid | cdi_proquest_miscellaneous_71581977 |
source | MEDLINE; Springer Nature - Complete Springer Journals |
subjects | Cell Cycle Proteins Circadian Rhythm - drug effects Circadian Rhythm - genetics Cyclic AMP Response Element-Binding Protein - drug effects Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - drug effects Cyclic AMP-Dependent Protein Kinases - metabolism Dichlororibofuranosylbenzimidazole - analogs & derivatives Dichlororibofuranosylbenzimidazole - pharmacology Dose-Response Relationship, Drug Eukaryotic Cells - drug effects Eukaryotic Cells - metabolism Feedback - drug effects Feedback - physiology Genes Genes, Reporter - drug effects Genes, Reporter - genetics Homeostasis - drug effects Homeostasis - genetics Humans Interleukin-6 - metabolism Interleukin-6 - pharmacology Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Nuclear Proteins - genetics Period Circadian Proteins Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Signal Transduction - drug effects Signal Transduction - genetics Sleep - drug effects Sleep - genetics Thionucleotides - pharmacology Tumor Cells, Cultured |
title | The human PER1 gene is inducible by interleukin-6 |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T21%3A21%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20human%20PER1%20gene%20is%20inducible%20by%20interleukin-6&rft.jtitle=Journal%20of%20molecular%20neuroscience&rft.au=Motzkus,%20Dirk&rft.date=2002-02-01&rft.volume=18&rft.issue=1-2&rft.spage=105&rft.epage=110&rft.pages=105-110&rft.issn=0895-8696&rft.eissn=0895-8696&rft_id=info:doi/10.1385/JMN:18:1-2:105&rft_dat=%3Cproquest_cross%3E2419979991%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=881662406&rft_id=info:pmid/11931340&rfr_iscdi=true |