The human PER1 gene is inducible by interleukin-6

The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the...

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Veröffentlicht in:Journal of molecular neuroscience 2002-02, Vol.18 (1-2), p.105-110
Hauptverfasser: Motzkus, Dirk, Albrecht, Urs, Maronde, Erik
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container_title Journal of molecular neuroscience
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creator Motzkus, Dirk
Albrecht, Urs
Maronde, Erik
description The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters.
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subjects Cell Cycle Proteins
Circadian Rhythm - drug effects
Circadian Rhythm - genetics
Cyclic AMP Response Element-Binding Protein - drug effects
Cyclic AMP Response Element-Binding Protein - metabolism
Cyclic AMP-Dependent Protein Kinases - drug effects
Cyclic AMP-Dependent Protein Kinases - metabolism
Dichlororibofuranosylbenzimidazole - analogs & derivatives
Dichlororibofuranosylbenzimidazole - pharmacology
Dose-Response Relationship, Drug
Eukaryotic Cells - drug effects
Eukaryotic Cells - metabolism
Feedback - drug effects
Feedback - physiology
Genes
Genes, Reporter - drug effects
Genes, Reporter - genetics
Homeostasis - drug effects
Homeostasis - genetics
Humans
Interleukin-6 - metabolism
Interleukin-6 - pharmacology
Mitogen-Activated Protein Kinases - drug effects
Mitogen-Activated Protein Kinases - metabolism
Nuclear Proteins - genetics
Period Circadian Proteins
Promoter Regions, Genetic - drug effects
Promoter Regions, Genetic - genetics
Signal Transduction - drug effects
Signal Transduction - genetics
Sleep - drug effects
Sleep - genetics
Thionucleotides - pharmacology
Tumor Cells, Cultured
title The human PER1 gene is inducible by interleukin-6
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