The human PER1 gene is inducible by interleukin-6

The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the...

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Veröffentlicht in:	Journal of molecular neuroscience 2002-02, Vol.18 (1-2), p.105-110
Hauptverfasser:	Motzkus, Dirk, Albrecht, Urs, Maronde, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins Circadian Rhythm - drug effects Circadian Rhythm - genetics Cyclic AMP Response Element-Binding Protein - drug effects Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - drug effects Cyclic AMP-Dependent Protein Kinases - metabolism Dichlororibofuranosylbenzimidazole - analogs & derivatives Dichlororibofuranosylbenzimidazole - pharmacology Dose-Response Relationship, Drug Eukaryotic Cells - drug effects Eukaryotic Cells - metabolism Feedback - drug effects Feedback - physiology Genes Genes, Reporter - drug effects Genes, Reporter - genetics Homeostasis - drug effects Homeostasis - genetics Humans Interleukin-6 - metabolism Interleukin-6 - pharmacology Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Nuclear Proteins - genetics Period Circadian Proteins Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Signal Transduction - drug effects Signal Transduction - genetics Sleep - drug effects Sleep - genetics Thionucleotides - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters.
ISSN:	0895-8696 0895-8696 1559-1166
DOI:	10.1385/JMN:18:1-2:105