Vinexin, CAP/ponsin, ArgBP2: a Novel Adaptor Protein Family Regulating Cytoskeletal Organization and Signal Transduction

Adaptor proteins, composed of two or more protein-protein interacting modules without enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2 constitute a novel adaptor protein family. They have a novel conserved region homologous to the active peptide sorbin, as wel...

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Veröffentlicht in:	Cell Structure and Function 2002, Vol.27(1), pp.1-7
Hauptverfasser:	Kioka, Noriyuki, Ueda, Kazumitsu, Amachi, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing anchorage-dependence Animals Cell Adhesion - physiology Cytoskeleton - metabolism Cytoskeleton - physiology Glucose Transporter Type 4 Growth Substances - metabolism Homeodomain Proteins - metabolism Humans insulin Insulin - metabolism Microfilament Proteins - metabolism Monosaccharide Transport Proteins - metabolism Muscle Proteins - chemistry Muscle Proteins - metabolism Protein Transport Proteins - metabolism RNA-Binding Proteins SH3 Signal Transduction - physiology sorbin src Homology Domains vinexin
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Beschreibung
Zusammenfassung:	Adaptor proteins, composed of two or more protein-protein interacting modules without enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2 constitute a novel adaptor protein family. They have a novel conserved region homologous to the active peptide sorbin, as well as three SH3 (src homology 3) domains. A number of proteins binding to this adaptor family have been identified. There is accumulating evidence that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor signaling. This review will summarize the structure and the function of proteins in this family.
ISSN:	0386-7196 1347-3700
DOI:	10.1247/csf.27.1