Inhibition of JNK by HGF/SF Prevents Apoptosis Induced by TNF-α

: We investigated whether repression of JNK by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF‐α, a well‐known inducer of JNK and of cell death, and the effects of HGF/SF we...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.100-103
Hauptverfasser: REVENEAU, SYLVIE, PAUMELLE, RÉJANE, DEHEUNINCK, JULIEN, LEROY, CATHERINE, DE LAUNOIT, YVAN, FAFEUR, VÉRONIQUE
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Sprache:eng
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Zusammenfassung:: We investigated whether repression of JNK by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF‐α, a well‐known inducer of JNK and of cell death, and the effects of HGF/SF were investigated under these conditions. We identified repression of JNK as a signaling target of HGF/SF for protection against TNF‐α‐induced cell death. This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1299.016