Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats

Vascular endothelial growth factor (VEGF) induces hypotension in normotensive subjects, which is considered to be a major side effect for treatment of ischemic diseases. However, the hypotensive effect of VEGF has not been investigated in the setting of hypertension. This study determined effects of...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-03, Vol.39 (3), p.815-820
Hauptverfasser:	Yang, Renhui, Ogasawara, Annie K, Zioncheck, Thomas F, Ren, Zhen, He, Guo-Wei, DeGuzman, Geralyn G, Pelletier, Nicolas, Shen, Ben-Quan, Bunting, Stuart, Jin, Hongkui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Dose-Response Relationship, Drug Endothelial Growth Factors - pharmacokinetics Endothelial Growth Factors - pharmacology Epoprostenol - blood Experimental diseases Heart Rate - drug effects Hypertension - drug therapy Hypertension - metabolism Hypertension - physiopathology In Vitro Techniques Lymphokines - pharmacokinetics Lymphokines - pharmacology Male Medical sciences Mesenteric Arteries - drug effects Mesenteric Arteries - physiology Nitric Oxide - blood Rats Rats, Inbred SHR Rats, Inbred WKY Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Vasodilation - drug effects
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Zusammenfassung:	Vascular endothelial growth factor (VEGF) induces hypotension in normotensive subjects, which is considered to be a major side effect for treatment of ischemic diseases. However, the hypotensive effect of VEGF has not been investigated in the setting of hypertension. This study determined effects of VEGF on hemodynamics, pharmacokinetics, and release of NO and prostaglandin I2 (PGI2) in vivo and on vasorelaxation of mesentery artery rings in vitro in spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY). Intravenous infusion of VEGF for 2 hours produced a dose-related decrease in arterial pressure, which was enhanced in conscious SHR compared with WKY (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/hy0302.105398