Quasi-steady state assumptions for non-isolated enzyme-catalysed reactions

Quasi-steady state assumptions for non-isolated enzyme-catalysed reactions

The nature and validity of the mathematical formulation of Michaelis-Menten type kinetics for enzyme-catalysed biochemical reactions is studied. Almost all previous work has concentrated on isolated reactions, i.e. those without input or other environmental influences. In this paper, we investigate...

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Veröffentlicht in:Journal of mathematical biology 2004-01, Vol.48 (1), p.82-104
Hauptverfasser: Stoleriu, I, Davidson, F A, Liu, J L
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Catalysis
Data Interpretation, Statistical
Enzymes - chemistry
Kinetics
Models, Chemical
Substrate Specificity
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Zusammenfassung:The nature and validity of the mathematical formulation of Michaelis-Menten type kinetics for enzyme-catalysed biochemical reactions is studied. Almost all previous work has concentrated on isolated reactions, i.e. those without input or other environmental influences. In this paper, we investigate the effects of substrate input on this formulation, in particular, on the nature and validity of the quasi-steady state assumptions.
ISSN:0303-6812
1432-1416
DOI:10.1007/s00285-003-0225-7