Structure–activity relationships of novel potent MurF inhibitors

A novel class of MurF inhibitors was discovered and structure–activity relationship studies have led to several potent compounds with IC 50=22∼70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers. A novel class of MurF inhibitors was discovered and structure–activity relationship studies have led to several potent compounds with IC 50=22∼70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.