Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: An event-related potential study
The auditory mismatch negativity (MMN) event-related brain potential (ERP) reflects the storage of information in acoustic sensory memory. Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 rec...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-05, Vol.72 (1), p.457-464 |
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| creator | Engeland, C. Mahoney, C. Mohr, E. Ilivitsky, V. Knott, Verner J. |
| description | The auditory mismatch negativity (MMN) event-related brain potential (ERP) reflects the storage of information in acoustic sensory memory. Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. MMNs were recorded with 1- and 3-s interstimulus intervals (ISIs) during pre- and post-placebo/nicotine administration. Amplitudes decreased from pre- to post-placebo recordings in nontreated patients but remained stable in THA-treated patients. Comparison of pre- and post-nicotine MMNs found amplitude increases with nicotine in nontreated but not in THA-treated patients. MMN latencies were shortened by nicotine in both treatment groups. These exploratory findings suggest that nicotine-improved strength of acoustic sensory memory traces and speed of acoustic sensory discrimination in AD are differentially affected by chronic tacrine treatment. |
| doi_str_mv | 10.1016/S0091-3057(02)00711-6 |
| format | Article |
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Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. MMNs were recorded with 1- and 3-s interstimulus intervals (ISIs) during pre- and post-placebo/nicotine administration. Amplitudes decreased from pre- to post-placebo recordings in nontreated patients but remained stable in THA-treated patients. Comparison of pre- and post-nicotine MMNs found amplitude increases with nicotine in nontreated but not in THA-treated patients. MMN latencies were shortened by nicotine in both treatment groups. These exploratory findings suggest that nicotine-improved strength of acoustic sensory memory traces and speed of acoustic sensory discrimination in AD are differentially affected by chronic tacrine treatment.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(02)00711-6</identifier><identifier>PMID: 11900820</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetylcholine ; Acoustic Stimulation - methods ; Aged ; Aged, 80 and over ; Alzheimer Disease - drug therapy ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Alzheimer's disease ; Analysis of Variance ; Biological and medical sciences ; Cholinergic system ; Cross-Over Studies ; Double-Blind Method ; ERPs ; Event-related potentials ; Evoked Potentials, Auditory - drug effects ; Evoked Potentials, Auditory - physiology ; Female ; Humans ; Male ; Medical sciences ; Memory - drug effects ; Memory - physiology ; Middle Aged ; Mismatch negativity ; MMN ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Nicotine ; Nicotine - administration & dosage ; Pharmacology. Drug treatments ; Sensory memory ; Tacrine ; Tacrine - therapeutic use</subject><ispartof>Pharmacology, biochemistry and behavior, 2002-05, Vol.72 (1), p.457-464</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-11d2c2dcef881123be65555cdad18e99d0e9986f64721b0c79914d3d027164153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(02)00711-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14546184$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11900820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engeland, C.</creatorcontrib><creatorcontrib>Mahoney, C.</creatorcontrib><creatorcontrib>Mohr, E.</creatorcontrib><creatorcontrib>Ilivitsky, V.</creatorcontrib><creatorcontrib>Knott, Verner J.</creatorcontrib><title>Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: An event-related potential study</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The auditory mismatch negativity (MMN) event-related brain potential (ERP) reflects the storage of information in acoustic sensory memory. Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. MMNs were recorded with 1- and 3-s interstimulus intervals (ISIs) during pre- and post-placebo/nicotine administration. Amplitudes decreased from pre- to post-placebo recordings in nontreated patients but remained stable in THA-treated patients. Comparison of pre- and post-nicotine MMNs found amplitude increases with nicotine in nontreated but not in THA-treated patients. MMN latencies were shortened by nicotine in both treatment groups. These exploratory findings suggest that nicotine-improved strength of acoustic sensory memory traces and speed of acoustic sensory discrimination in AD are differentially affected by chronic tacrine treatment.</description><subject>Acetylcholine</subject><subject>Acoustic Stimulation - methods</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cholinergic system</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>ERPs</subject><subject>Event-related potentials</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Middle Aged</subject><subject>Mismatch negativity</subject><subject>MMN</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Nicotine</subject><subject>Nicotine - administration & dosage</subject><subject>Pharmacology. Drug treatments</subject><subject>Sensory memory</subject><subject>Tacrine</subject><subject>Tacrine - therapeutic use</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc9u1DAQxi0EokvhEUC-8O8QmHESO-kFrSoolSr1AJwtrz1RjRJnsZ2i5UV4XbzdbZnDfBrpNyPN9zH2EuEDAsqP3wB6rGpo1TsQ7wEUYiUfsRV2qq5aVOoxWz0gJ-xZSj8BoBFSPWUniD1AJ2DF_q7tkokHb-fsA3EaBrI58Tlwszif57jjiULa60TTXnzg2dhY6CpHMpkcN8HxMIf7cWuyp1Cu_Pb5hq_HPzfkJ4pvE3c-kUl0xteB021hqkjjYWfOZfRm5CkvbvecPRnMmOjFUU_Zjy-fv59_ra6uLy7P11eVrZs2V4hOWOEsDV2HKOoNybaUdcZhR33voLRODrJRAjdgVd9j42oHQqFssK1P2ZvD3W2cfy2Usp58sjSOJtC8JK2wlaqYVsBXR3DZTOT0NvrJxJ2-t7IAr4-ASdaMQzTB-vSfa9pGYtcU7tOBo_LWraeoky1uWXI-Fuu1m71G0PuQ9V3Iep-gBqHvQtay_gfU3JpW</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Engeland, C.</creator><creator>Mahoney, C.</creator><creator>Mohr, E.</creator><creator>Ilivitsky, V.</creator><creator>Knott, Verner J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: An event-related potential study</title><author>Engeland, C. ; Mahoney, C. ; Mohr, E. ; Ilivitsky, V. ; Knott, Verner J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-11d2c2dcef881123be65555cdad18e99d0e9986f64721b0c79914d3d027164153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetylcholine</topic><topic>Acoustic Stimulation - methods</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Cholinergic system</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>ERPs</topic><topic>Event-related potentials</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Middle Aged</topic><topic>Mismatch negativity</topic><topic>MMN</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Nicotine</topic><topic>Nicotine - administration & dosage</topic><topic>Pharmacology. Drug treatments</topic><topic>Sensory memory</topic><topic>Tacrine</topic><topic>Tacrine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engeland, C.</creatorcontrib><creatorcontrib>Mahoney, C.</creatorcontrib><creatorcontrib>Mohr, E.</creatorcontrib><creatorcontrib>Ilivitsky, V.</creatorcontrib><creatorcontrib>Knott, Verner J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engeland, C.</au><au>Mahoney, C.</au><au>Mohr, E.</au><au>Ilivitsky, V.</au><au>Knott, Verner J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: An event-related potential study</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>72</volume><issue>1</issue><spage>457</spage><epage>464</epage><pages>457-464</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The auditory mismatch negativity (MMN) event-related brain potential (ERP) reflects the storage of information in acoustic sensory memory. Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. MMNs were recorded with 1- and 3-s interstimulus intervals (ISIs) during pre- and post-placebo/nicotine administration. Amplitudes decreased from pre- to post-placebo recordings in nontreated patients but remained stable in THA-treated patients. Comparison of pre- and post-nicotine MMNs found amplitude increases with nicotine in nontreated but not in THA-treated patients. MMN latencies were shortened by nicotine in both treatment groups. These exploratory findings suggest that nicotine-improved strength of acoustic sensory memory traces and speed of acoustic sensory discrimination in AD are differentially affected by chronic tacrine treatment.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11900820</pmid><doi>10.1016/S0091-3057(02)00711-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Acetylcholine Acoustic Stimulation - methods Aged Aged, 80 and over Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Alzheimer Disease - psychology Alzheimer's disease Analysis of Variance Biological and medical sciences Cholinergic system Cross-Over Studies Double-Blind Method ERPs Event-related potentials Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Female Humans Male Medical sciences Memory - drug effects Memory - physiology Middle Aged Mismatch negativity MMN Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Nicotine Nicotine - administration & dosage Pharmacology. Drug treatments Sensory memory Tacrine Tacrine - therapeutic use |
| title | Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: An event-related potential study |
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