Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: An event-related potential study

The auditory mismatch negativity (MMN) event-related brain potential (ERP) reflects the storage of information in acoustic sensory memory. Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 rec...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-05, Vol.72 (1), p.457-464
Hauptverfasser: Engeland, C., Mahoney, C., Mohr, E., Ilivitsky, V., Knott, Verner J.
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Sprache:eng
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Zusammenfassung:The auditory mismatch negativity (MMN) event-related brain potential (ERP) reflects the storage of information in acoustic sensory memory. Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. MMNs were recorded with 1- and 3-s interstimulus intervals (ISIs) during pre- and post-placebo/nicotine administration. Amplitudes decreased from pre- to post-placebo recordings in nontreated patients but remained stable in THA-treated patients. Comparison of pre- and post-nicotine MMNs found amplitude increases with nicotine in nontreated but not in THA-treated patients. MMN latencies were shortened by nicotine in both treatment groups. These exploratory findings suggest that nicotine-improved strength of acoustic sensory memory traces and speed of acoustic sensory discrimination in AD are differentially affected by chronic tacrine treatment.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(02)00711-6