Lexipafant Inhibits Postsurgical Adhesion Formation

Background. PAF and its antagonists have been studied in the pathophysiology of various inflammatory conditions. This study investigates the effects of a platelet activating factor antagonist, lexipafant, on peritoneal adhesion formation and wound healing. Materials and methods. Forty-eight Wistar a...

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Veröffentlicht in:The Journal of surgical research 2002-04, Vol.103 (2), p.141-145
Hauptverfasser: Özgün, Hedef, Çevikel, Mehmet Hakan, Kozaci, Leyla Didem, Sakarya, Serhan
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Sprache:eng
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Zusammenfassung:Background. PAF and its antagonists have been studied in the pathophysiology of various inflammatory conditions. This study investigates the effects of a platelet activating factor antagonist, lexipafant, on peritoneal adhesion formation and wound healing. Materials and methods. Forty-eight Wistar albino rats (300–350 g) were divided into four equal groups; adhesion-induced lexipafant (AL), adhesion-induced saline (AS), sham-operated lexipafant (SL), and sham-operated saline (SS). All rats underwent a midline laparotomy under sterile conditions. The anterior wall of the left uterine horn was scraped to cause hemorrhages in adhesion-induced groups. Following peritoneal injections of either saline or lexipafant, the incisions were closed in layers. On the 14th day, the rats were killed and adhesions were scored from 0 (none) to 4 (dense). Tissue samples from the adhesions and the left horn of uterus were examined biochemically for hydroxyproline content, and serum IL-6 levels were determined. Results. The adhesion formation score was significantly increased in the AS group compared to the SL and AL groups (P < 0.001). The IL-6 levels of the AS group were higher than those of the other groups (P < 0.05). There was no significant difference in hydroxyproline content between groups (P > 0.05). Conclusions. Lexipafant plays a role in the prevention of adhesion formation without affecting wound healing.
ISSN:0022-4804
1095-8673
DOI:10.1006/jsre.2002.6357