Lexipafant Inhibits Postsurgical Adhesion Formation
Background. PAF and its antagonists have been studied in the pathophysiology of various inflammatory conditions. This study investigates the effects of a platelet activating factor antagonist, lexipafant, on peritoneal adhesion formation and wound healing. Materials and methods. Forty-eight Wistar a...
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Veröffentlicht in: | The Journal of surgical research 2002-04, Vol.103 (2), p.141-145 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background. PAF and its antagonists have been studied in the pathophysiology of various inflammatory conditions. This study investigates the effects of a platelet activating factor antagonist, lexipafant, on peritoneal adhesion formation and wound healing.
Materials and methods. Forty-eight Wistar albino rats (300–350 g) were divided into four equal groups; adhesion-induced lexipafant (AL), adhesion-induced saline (AS), sham-operated lexipafant (SL), and sham-operated saline (SS). All rats underwent a midline laparotomy under sterile conditions. The anterior wall of the left uterine horn was scraped to cause hemorrhages in adhesion-induced groups. Following peritoneal injections of either saline or lexipafant, the incisions were closed in layers. On the 14th day, the rats were killed and adhesions were scored from 0 (none) to 4 (dense). Tissue samples from the adhesions and the left horn of uterus were examined biochemically for hydroxyproline content, and serum IL-6 levels were determined.
Results. The adhesion formation score was significantly increased in the AS group compared to the SL and AL groups (P < 0.001). The IL-6 levels of the AS group were higher than those of the other groups (P < 0.05). There was no significant difference in hydroxyproline content between groups (P > 0.05).
Conclusions. Lexipafant plays a role in the prevention of adhesion formation without affecting wound healing. |
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ISSN: | 0022-4804 1095-8673 |
DOI: | 10.1006/jsre.2002.6357 |