Inhibition of Apoptosis by Amphiregulin via an Insulin-like Growth Factor-1 Receptor-Dependent Pathway in Non-Small Cell Lung Cancer Cell Lines

: The reciprocal activation of amphiregulin (AR) and insulin‐like growth factor‐1 (IGF1) pathways has been shown to induce inhibition of serum deprivation apoptosis in non‐small cell lung cancer (NSCLC) cell lines H358 and H322. We demonstrated that AR activated the IGF1 receptor (IGF1‐R), which in turn induced the secretion of AR and IGF1. Transactivation of the IGF1‐R by AR is independent of its binding to EGFR. Thus, AR can inhibit apoptosis in NSCLC cells through an IGF1‐R‐dependent pathway.