Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

: Antioxidants‐that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)‐protect monocytic U937 cells from damage‐induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.441-445
Hauptverfasser:	LIUZZI, FRANCESCA, FANELLI, CLAUDIA, CIRIOLO, MARIA ROSA, CERELLA, CLAUDIA, D'ALESSIO, MARIA, DENICOLA, MILENA, MAGRINI, ANDREA, BERGAMASCHI, ANTONIO, GHIBELLI, LINA
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobiosis antioxidants Antioxidants - pharmacology apoptosis Apoptosis - drug effects Apoptosis - physiology Cell Hypoxia - physiology Cell Survival - drug effects glutathione Glutathione - physiology Humans Puromycin - pharmacology U937 Cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	445
container_issue	1
container_start_page	441
container_title	Annals of the New York Academy of Sciences
container_volume	1010
creator	LIUZZI, FRANCESCA FANELLI, CLAUDIA CIRIOLO, MARIA ROSA CERELLA, CLAUDIA D'ALESSIO, MARIA DENICOLA, MILENA MAGRINI, ANDREA BERGAMASCHI, ANTONIO GHIBELLI, LINA
description	: Antioxidants‐that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)‐protect monocytic U937 cells from damage‐induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress‐induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiols oxidation and radical production.
doi_str_mv	10.1196/annals.1299.080
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71560633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71560633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3761-59fb64ea274116474adef36d0c751600653ae2a85a05ae379d4d6abe53a0cb553</originalsourceid><addsrcrecordid>eNqFkM1LwzAYh4MoOj_O3iQnb51J87Uex9yHMBy4ieglpG0K1bWZeVu2_fdmdOjRU-Dl9_zevA9Ct5T0KU3kg6lrs4Y-jZOkTwbkBPWo4kkkJYtPUY8QpaJBErMLdAnwSQiNB1ydowsqCGNKqh5avljIWotdgUd2vQZceFfh4cZtGgcl4HSPh3VTul2Zm7oBvMiy1gN-dNsaGm9N1QHT5QyPd41voXT1NTorwq_szfG9Qq-T8Wo0i-aL6dNoOI-ysJtGIilSya2JFadUcsVNbgsmc5IpQSUhUjBjYzMQhghjmUpynkuT2jAmWSoEu0L3Xe_Gu-_WQqOrErJwhamta0ErKiSRjIXgQxfMvAPwttAbX1bG7zUl-uBRdx71waMOHgNxd6xu08rmf_mjuBDgXWBbru3-vz79_D5cck4DFnVYCY3d_WLGf-lQqoR-e57qj4la8dXjXHP2Axhaj2o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71560633</pqid></control><display><type>article</type><title>Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>LIUZZI, FRANCESCA ; FANELLI, CLAUDIA ; CIRIOLO, MARIA ROSA ; CERELLA, CLAUDIA ; D'ALESSIO, MARIA ; DENICOLA, MILENA ; MAGRINI, ANDREA ; BERGAMASCHI, ANTONIO ; GHIBELLI, LINA</creator><creatorcontrib>LIUZZI, FRANCESCA ; FANELLI, CLAUDIA ; CIRIOLO, MARIA ROSA ; CERELLA, CLAUDIA ; D'ALESSIO, MARIA ; DENICOLA, MILENA ; MAGRINI, ANDREA ; BERGAMASCHI, ANTONIO ; GHIBELLI, LINA</creatorcontrib><description>: Antioxidants‐that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)‐protect monocytic U937 cells from damage‐induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress‐induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiols oxidation and radical production.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1299.080</identifier><identifier>PMID: 15033767</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anaerobiosis ; antioxidants ; Antioxidants - pharmacology ; apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Cell Hypoxia - physiology ; Cell Survival - drug effects ; glutathione ; Glutathione - physiology ; Humans ; Puromycin - pharmacology ; U937 Cells</subject><ispartof>Annals of the New York Academy of Sciences, 2003-12, Vol.1010 (1), p.441-445</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3761-59fb64ea274116474adef36d0c751600653ae2a85a05ae379d4d6abe53a0cb553</citedby><cites>FETCH-LOGICAL-c3761-59fb64ea274116474adef36d0c751600653ae2a85a05ae379d4d6abe53a0cb553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1299.080$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1299.080$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15033767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIUZZI, FRANCESCA</creatorcontrib><creatorcontrib>FANELLI, CLAUDIA</creatorcontrib><creatorcontrib>CIRIOLO, MARIA ROSA</creatorcontrib><creatorcontrib>CERELLA, CLAUDIA</creatorcontrib><creatorcontrib>D'ALESSIO, MARIA</creatorcontrib><creatorcontrib>DENICOLA, MILENA</creatorcontrib><creatorcontrib>MAGRINI, ANDREA</creatorcontrib><creatorcontrib>BERGAMASCHI, ANTONIO</creatorcontrib><creatorcontrib>GHIBELLI, LINA</creatorcontrib><title>Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: Antioxidants‐that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)‐protect monocytic U937 cells from damage‐induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress‐induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiols oxidation and radical production.</description><subject>Anaerobiosis</subject><subject>antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Cell Hypoxia - physiology</subject><subject>Cell Survival - drug effects</subject><subject>glutathione</subject><subject>Glutathione - physiology</subject><subject>Humans</subject><subject>Puromycin - pharmacology</subject><subject>U937 Cells</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LwzAYh4MoOj_O3iQnb51J87Uex9yHMBy4ieglpG0K1bWZeVu2_fdmdOjRU-Dl9_zevA9Ct5T0KU3kg6lrs4Y-jZOkTwbkBPWo4kkkJYtPUY8QpaJBErMLdAnwSQiNB1ydowsqCGNKqh5avljIWotdgUd2vQZceFfh4cZtGgcl4HSPh3VTul2Zm7oBvMiy1gN-dNsaGm9N1QHT5QyPd41voXT1NTorwq_szfG9Qq-T8Wo0i-aL6dNoOI-ysJtGIilSya2JFadUcsVNbgsmc5IpQSUhUjBjYzMQhghjmUpynkuT2jAmWSoEu0L3Xe_Gu-_WQqOrErJwhamta0ErKiSRjIXgQxfMvAPwttAbX1bG7zUl-uBRdx71waMOHgNxd6xu08rmf_mjuBDgXWBbru3-vz79_D5cck4DFnVYCY3d_WLGf-lQqoR-e57qj4la8dXjXHP2Axhaj2o</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>LIUZZI, FRANCESCA</creator><creator>FANELLI, CLAUDIA</creator><creator>CIRIOLO, MARIA ROSA</creator><creator>CERELLA, CLAUDIA</creator><creator>D'ALESSIO, MARIA</creator><creator>DENICOLA, MILENA</creator><creator>MAGRINI, ANDREA</creator><creator>BERGAMASCHI, ANTONIO</creator><creator>GHIBELLI, LINA</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion</title><author>LIUZZI, FRANCESCA ; FANELLI, CLAUDIA ; CIRIOLO, MARIA ROSA ; CERELLA, CLAUDIA ; D'ALESSIO, MARIA ; DENICOLA, MILENA ; MAGRINI, ANDREA ; BERGAMASCHI, ANTONIO ; GHIBELLI, LINA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3761-59fb64ea274116474adef36d0c751600653ae2a85a05ae379d4d6abe53a0cb553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anaerobiosis</topic><topic>antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Cell Hypoxia - physiology</topic><topic>Cell Survival - drug effects</topic><topic>glutathione</topic><topic>Glutathione - physiology</topic><topic>Humans</topic><topic>Puromycin - pharmacology</topic><topic>U937 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIUZZI, FRANCESCA</creatorcontrib><creatorcontrib>FANELLI, CLAUDIA</creatorcontrib><creatorcontrib>CIRIOLO, MARIA ROSA</creatorcontrib><creatorcontrib>CERELLA, CLAUDIA</creatorcontrib><creatorcontrib>D'ALESSIO, MARIA</creatorcontrib><creatorcontrib>DENICOLA, MILENA</creatorcontrib><creatorcontrib>MAGRINI, ANDREA</creatorcontrib><creatorcontrib>BERGAMASCHI, ANTONIO</creatorcontrib><creatorcontrib>GHIBELLI, LINA</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIUZZI, FRANCESCA</au><au>FANELLI, CLAUDIA</au><au>CIRIOLO, MARIA ROSA</au><au>CERELLA, CLAUDIA</au><au>D'ALESSIO, MARIA</au><au>DENICOLA, MILENA</au><au>MAGRINI, ANDREA</au><au>BERGAMASCHI, ANTONIO</au><au>GHIBELLI, LINA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2003-12</date><risdate>2003</risdate><volume>1010</volume><issue>1</issue><spage>441</spage><epage>445</epage><pages>441-445</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Antioxidants‐that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)‐protect monocytic U937 cells from damage‐induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress‐induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiols oxidation and radical production.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15033767</pmid><doi>10.1196/annals.1299.080</doi><tpages>5</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0077-8923
ispartof	Annals of the New York Academy of Sciences, 2003-12, Vol.1010 (1), p.441-445
issn	0077-8923 1749-6632
language	eng
recordid	cdi_proquest_miscellaneous_71560633
source	MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects	Anaerobiosis antioxidants Antioxidants - pharmacology apoptosis Apoptosis - drug effects Apoptosis - physiology Cell Hypoxia - physiology Cell Survival - drug effects glutathione Glutathione - physiology Humans Puromycin - pharmacology U937 Cells
title	Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T18%3A33%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rescue%20of%20Cells%20from%20Apoptosis%20by%20Antioxidants%20Occurs%20Downstream%20from%20GSH%20Extrusion&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=LIUZZI,%20FRANCESCA&rft.date=2003-12&rft.volume=1010&rft.issue=1&rft.spage=441&rft.epage=445&rft.pages=441-445&rft.issn=0077-8923&rft.eissn=1749-6632&rft_id=info:doi/10.1196/annals.1299.080&rft_dat=%3Cproquest_cross%3E71560633%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71560633&rft_id=info:pmid/15033767&rfr_iscdi=true