Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

: Antioxidants‐that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)‐protect monocytic U937 cells from damage‐induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.441-445
Hauptverfasser: LIUZZI, FRANCESCA, FANELLI, CLAUDIA, CIRIOLO, MARIA ROSA, CERELLA, CLAUDIA, D'ALESSIO, MARIA, DENICOLA, MILENA, MAGRINI, ANDREA, BERGAMASCHI, ANTONIO, GHIBELLI, LINA
Format: Artikel
Sprache:eng
Schlagworte:
Anaerobiosis
antioxidants
Antioxidants - pharmacology
apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Cell Hypoxia - physiology
Cell Survival - drug effects
glutathione
Glutathione - physiology
Humans
Puromycin - pharmacology
U937 Cells
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:: Antioxidants‐that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)‐protect monocytic U937 cells from damage‐induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress‐induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiols oxidation and radical production.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1299.080