Carbachol in the pontine reticular formation of C57BL/6J mouse decreases acetylcholine release in prefrontal cortex

The prefrontal cortex and brainstem modulate autonomic and arousal state control but the neurotransmitter mechanisms underlying communication between prefrontal cortex and brainstem remain poorly understood. This study examined the hypothesis that microdialysis delivery of carbachol to the pontine r...

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Veröffentlicht in:	Neuroscience 2004, Vol.123 (1), p.17-29
Hauptverfasser:	Demarco, G.J, Baghdoyan, H.A, Lydic, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - antagonists & inhibitors Acetylcholine - metabolism Animals arousal basal forebrain Biological and medical sciences breathing Carbachol - pharmacology cortical excitability Fundamental and applied biological sciences. Psychology G proteins Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Male Mice Mice, Inbred C57BL Pons - drug effects Pons - metabolism Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Protein Binding - drug effects Protein Binding - physiology REM sleep Reticular Formation - drug effects Reticular Formation - metabolism Sleep. Vigilance Vertebrates: nervous system and sense organs
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Zusammenfassung:	The prefrontal cortex and brainstem modulate autonomic and arousal state control but the neurotransmitter mechanisms underlying communication between prefrontal cortex and brainstem remain poorly understood. This study examined the hypothesis that microdialysis delivery of carbachol to the pontine reticular formation (PRF) of anesthetized C57BL/6J (B6) mouse modulates acetylcholine (ACh) release in the frontal association cortex. Microdialysis delivery of carbachol (8.8 mM) to the PRF caused a significant ( P
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2003.08.045