Neuronal Death versus Synaptic Pathology in Alzheimer's Disease

: Neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and cerebellum of adult, old, and demented (Alzheimer's disease) patients. Our findings support the notion that synaptic loss represents per s...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.635-638
Hauptverfasser:	BERTONI-FREDDARI, CARLO, FATTORETTI, PATRIZIA, SOLAZZI, MORENO, GIORGETTI, BELINDA, DI STEFANO, GIUSEPPINA, CASOLI, TIZIANA, MEIER-RUGE, WILLIAM
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging Alzheimer Disease - pathology Alzheimer's disease apoptosis Brain - growth & development Brain - pathology cerebellum Cerebellum - pathology hippocampus Hippocampus - pathology Humans neuron density neuronal death Neurons - pathology synapse-to-neuron ratio Synapses - pathology synaptic density synaptic plasticity
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Zusammenfassung:	: Neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and cerebellum of adult, old, and demented (Alzheimer's disease) patients. Our findings support the notion that synaptic loss represents per se a prominent and early damage affecting zones of the central nervous system reported to show a different vulnerability to age‐ and pathology‐related changes.
ISSN:	0077-8923 1749-6632
DOI:	10.1196/annals.1299.116