Membrane Estrogen Receptor-Dependent Extracellular Signal-Regulated Kinase Pathway Mediates Acute Activation of Endothelial Nitric Oxide Synthase by Estrogen in Uterine Artery Endothelial Cells

Rapid uterine vasodilatation after estrogen administration is believed to be mediated by endothelial production of nitric oxide (NO) via endothelial NO synthase (eNOS). However, the mechanism(s) by which estrogen activates eNOS in uterine artery endothelial cells (UAEC) is unknown. In this study, we...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-01, Vol.145 (1), p.113-125
Hauptverfasser:	Chen, Dong-bao, Bird, Ian M, Zheng, Jing, Magness, Ronald R
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Actinomycin AKT protein Animals Arteries - physiology Biological and medical sciences Calcium (intracellular) Calcium - metabolism Calcium ions Cell activation Cell Membrane - metabolism Endothelial cells Endothelium, Vascular - enzymology Enzyme Activation - drug effects Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Antagonists - pharmacology Estrogen Receptor alpha Estrogen receptors Estrogens Extracellular signal-regulated kinase Female Fluorescein isothiocyanate Fulvestrant Fundamental and applied biological sciences. Psychology Immunoblotting Insulin-Like Growth Factor I - pharmacology Ionomycin Kinases MAP Kinase Kinase 1 MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Membrane proteins Membranes Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Nitric-oxide synthase Nitrogen oxides Phosphorylation Phosphorylation - drug effects Pregnancy Protein Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-raf - metabolism Receptors Receptors, Estrogen - metabolism Serum Albumin, Bovine - pharmacology Sex hormones Sheep Uterus Uterus - blood supply Uterus - physiology Vasodilation Vasodilation - drug effects Vasodilation - physiology Vertebrates: endocrinology
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Zusammenfassung:	Rapid uterine vasodilatation after estrogen administration is believed to be mediated by endothelial production of nitric oxide (NO) via endothelial NO synthase (eNOS). However, the mechanism(s) by which estrogen activates eNOS in uterine artery endothelial cells (UAEC) is unknown. In this study, we observed that estradiol-17β (E2) and E2-BSA rapidly (
ISSN:	0013-7227 1945-7170
DOI:	10.1210/en.2003-0547