Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger

Experiments were performed to examine the effect of chronic inhibition of the Na(+)/H(+) exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, caripo...

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Veröffentlicht in:	Cardiovascular research 2002-03, Vol.53 (4), p.862-868
Hauptverfasser:	CAMILION DE HURTADO, Maria C, PORTIANSKY, Enrique L, PEREZ, Néstor G, REBOLLEDO, Oscar R, CINGOLANI, Horacio E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anti-Arrhythmia Agents - therapeutic use Antihypertensive agents Biological and medical sciences Cardiomegaly - blood Cardiomegaly - drug therapy Cardiomegaly - pathology Cardiovascular system Collagen Type I - blood Dose-Response Relationship, Drug Drug Administration Schedule Guanidines - therapeutic use Hypertension - blood Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred SHR Rats, Wistar Sodium-Hydrogen Exchangers - antagonists & inhibitors Sodium-Hydrogen Exchangers - physiology Sulfones - therapeutic use
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Zusammenfassung:	Experiments were performed to examine the effect of chronic inhibition of the Na(+)/H(+) exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of approximately 6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28+/-0.05 to 3.04+/-0.05 (0.3 mg) and 2.99+/-0.10 (3.0 mg, P
ISSN:	0008-6363 1755-3245
DOI:	10.1016/s0008-6363(01)00544-2