Protein Folding and Unfolding at Atomic Resolution

Protein Folding and Unfolding at Atomic Resolution

Experiment and simulation are now conspiring to give atomic-level descriptions of protein folding relevant to folding, misfolding, trafficking, and degradation in the cell. We are on the threshold of predicting those protein folding events using simulation that has been carefully benchmarked by expe...

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Veröffentlicht in:Cell 2002-02, Vol.108 (4), p.573-582
Hauptverfasser: Fersht, Alan R., Daggett, Valerie
Format: Artikel
Sprache:eng
Schlagworte:
Bacterial Proteins
Homeodomain Proteins - chemistry
Magnetic Resonance Spectroscopy
Models, Molecular
Peptides - chemistry
Plant Proteins
Protein Denaturation
Protein Folding
Protein Structure, Tertiary
Proteins - chemistry
Proteins - metabolism
Ribonucleases - chemistry
Transcription Factors
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Zusammenfassung:Experiment and simulation are now conspiring to give atomic-level descriptions of protein folding relevant to folding, misfolding, trafficking, and degradation in the cell. We are on the threshold of predicting those protein folding events using simulation that has been carefully benchmarked by experiment.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(02)00620-7