Gene-Specific Regulation by General Translation Factors

Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. Recent studies have enhanced our understanding of the translation initiation p...

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Veröffentlicht in:	Cell 2002-02, Vol.108 (4), p.545-556
1. Verfasser:	Dever, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 DNA-Binding Proteins Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation Macromolecular Substances Models, Biological Open Reading Frames Peptide Initiation Factors - metabolism Phosphorylation Protein Biosynthesis - physiology Protein Kinases - genetics Protein Kinases - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae Proteins Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. Recent studies have enhanced our understanding of the translation initiation process and helped elucidate how modifications of the general translational machinery regulate gene-specific protein production.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/S0092-8674(02)00642-6