Interactions of antifungal plant defensins with fungal membrane components

Plant defensins are small, basic, cysteine-rich peptides that are generally active against a broad spectrum of fungal and yeast species at micromolar concentrations. Some of these defensins interact with fungal-specific lipid components in the plasmamembrane. Structural differences of these membrane...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2003-11, Vol.24 (11), p.1705-1712
Hauptverfasser:	Thevissen, Karin, Ferket, Kathelijne K.A., François, Isabelle E.J.A., Cammue, Bruno P.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - metabolism Antifungal Agents - pharmacology Candida albicans Cell Membrane - chemistry Cell Membrane - drug effects Cell Membrane - metabolism cysteine defensins Defensins - metabolism Defensins - pharmacology Fungi - cytology Fungi - drug effects Fungi - metabolism Glucosylceramide Mode of action Models, Biological Neurospora crassa Pichia pastoris Plant defensin Plant Proteins - metabolism Plant Proteins - pharmacology Saccharomyces cerevisiae Sphingolipid
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Beschreibung
Zusammenfassung:	Plant defensins are small, basic, cysteine-rich peptides that are generally active against a broad spectrum of fungal and yeast species at micromolar concentrations. Some of these defensins interact with fungal-specific lipid components in the plasmamembrane. Structural differences of these membrane components between fungal and plant cells probably account for the selective activity of plant defensins against fungal pathogens and their nonphytotoxic properties. This review will focus on different classes of complex lipids in fungal membranes and on the selective interaction of plant defensins with these complex lipids.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/j.peptides.2003.09.014