Antibody increases phagocytosis and killing of Lactococcus garvieae by rainbow trout (Oncorhynchus mykiss, L.) macrophages

The present study reports that specific antibody increased the bactericidal activity of rainbow trout head-kidney macrophages against virulent capsulated Lactococcus garvieae in the absence of complement. The observed increased bactericidal activity appeared to result from increased phagocytosis of...

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Veröffentlicht in:	Fish & shellfish immunology 2002-02, Vol.12 (2), p.181-186
Hauptverfasser:	Barnes, Andrew C, Guyot, Céline, Hansen, Bjarne G, Horne, Michael T, Ellis, Anthony E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - blood Bacterial Capsules Blood Bactericidal Activity Cells, Cultured Complement System Proteins - immunology Kidney - cytology Kidney - immunology Lactococcus - immunology Lactococcus - pathogenicity Lactococcus garvieae Lactococcus garvieae, rainbow trout, antibody, macrophages, phagocytosis Macrophages - immunology Macrophages - microbiology Oncorhynchus mykiss Oncorhynchus mykiss - immunology Phagocytosis - immunology Virulence
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Zusammenfassung:	The present study reports that specific antibody increased the bactericidal activity of rainbow trout head-kidney macrophages against virulent capsulated Lactococcus garvieae in the absence of complement. The observed increased bactericidal activity appeared to result from increased phagocytosis of capsulated L. garvieae in the presence of specific antibody and may in part explain the protective effect of antibody previously reported against this disease.
ISSN:	1050-4648 1095-9947
DOI:	10.1006/fsim.2001.0372