New Quinones and Hydroquinones from Malbranchea cinnamomea HKI 286 and HKI 296 and Interaction with Tax/CREB Expression System in Yeast

In addition to malbranicin (1) and dihydromalbranicin (5), new substituted quinones 2, 3, 6 and hydroquinone 4 were isolated from the culture brothes of two strains of Malbranchea cinnamomea. The chemical constitutions of new metabolites 2, 3, 4 and 6 were elucidated by optical spectroscopy, mass sp...

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Veröffentlicht in:	Journal of antibiotics 2003/11/25, Vol.56(11), pp.917-922
Hauptverfasser:	SCHLEGEL, BRIGITTE, HÄNEL, FRANK, GOLLMICK, FRIEDRICH A., SALUZ, HANS-PETER, GRÄFE, UDO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cyclic AMP Response Element-Binding Protein - drug effects Genes, pX - drug effects Hydroquinones - chemistry Hydroquinones - isolation & purification Hydroquinones - pharmacology Malbranchea cinnamomea Medical sciences Pharmacology. Drug treatments Quinones - chemistry Quinones - isolation & purification Quinones - pharmacology Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Structure-Activity Relationship
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Zusammenfassung:	In addition to malbranicin (1) and dihydromalbranicin (5), new substituted quinones 2, 3, 6 and hydroquinone 4 were isolated from the culture brothes of two strains of Malbranchea cinnamomea. The chemical constitutions of new metabolites 2, 3, 4 and 6 were elucidated by optical spectroscopy, mass spectrometry and 1D/2D NMR spectroscopy. 2 (7-methoxymalbranicin) at a concentration of 42μM inhibited by 67% Tax/CREB-mediated expression of β-galactosidase in a recombinant strain of Saccharomyces cerevisiae.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.56.917