Elevated P/Q Type (Ñß1A) and L2 Type (Ñß1D) Purkinje Cell Voltage-gated Calcium Channels in the Cerebella of Seizure Prone Gerbils

Differences in expression of N-methyl-D-aspartate (NMDA) receptor and voltage gated Ca2+ channels (VGCC) in the gerbil cerebellum were investigated to identify routes of Ca2+ influx that may be involved in purkinje cell damage. Immunodensities of NR1 and NR2A/B were the same in seizure resistant (SR...

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Veröffentlicht in:	Molecules and cells 2003-12, Vol.16 (3), p.297-301
Hauptverfasser:	Park, S.K, Hwang, I.K, An, S.J, Won, M.H, Kang, T.J. (Hallym University, Chunchon, Republic of Korea)
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels - immunology Calcium Channels - metabolism Cerebellum - immunology Cerebellum - metabolism EPILEPSY Gerbillinae - immunology Gerbillinae - metabolism GERBILS Immunoblotting Immunohistochemistry Purkinje Cells - immunology Purkinje Cells - metabolism Receptors, N-Methyl-D-Aspartate - immunology
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Zusammenfassung:	Differences in expression of N-methyl-D-aspartate (NMDA) receptor and voltage gated Ca2+ channels (VGCC) in the gerbil cerebellum were investigated to identify routes of Ca2+ influx that may be involved in purkinje cell damage. Immunodensities of NR1 and NR2A/B were the same in seizure resistant (SR) and seizure sensitive (SS) gerbils than in those of SR gerbils, whereas N type (Ñß1B) nd L1 type (Ñß1C) VGCC levels were similar in the two groups.
ISSN:	1016-8478
DOI:	10.1016/S1016-8478(23)13804-0