Spontaneous Clearance of High-Titer Serum HBV DNA and Risk of Hepatocellular Carcinoma in a Chinese Population
Chronic hepatitis B virus (HBV) carriers with high-titer viremia ($>10^{5}$ virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a...
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| Veröffentlicht in: | Cancer causes & control 2003-12, Vol.14 (10), p.995-1000 |
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| creator | Harris, Rebecca A. Chen, Gang Lin, Wen Yao Shen, Fu Min London, W. Thomas Evans, Alison A. |
| description | Chronic hepatitis B virus (HBV) carriers with high-titer viremia ($>10^{5}$ virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a prospective cohort of 114 adults from Haimen City, China, all HBV DNA(+) at study entry and followed for 797.8 person-years in total. During follow-up, 54 (47.4%) subjects spontaneously cleared high-titer viremia at least once. Of these, 27 were considered to have undergone stable seroconversion, 16 were considered unstable (12 reversions to HBV DNA positivity and 4 multiple clearances), and 11 did not have sufficient follow-up to determine stability. Of the 114 persons, 26 (22.8%) died during follow-up, 21 (18.4%) from HCC. Using Cox proportional hazards models, the RR of HCC death associated with seroconversion was 2.8 (95% CI = 1.1-7.4), controlling for age, sex, family HCC history, history of acute hepatitis, alcohol use and cigarette smoking. In conclusion, fluctuations of high-titer viremia may indicate increased hepatocellular damage and at least short-term increases in HCC risk. Long-term longitudinal studies are needed to clarify this relationship and its potential usefulness as a prognostic marker in chronic HBV infection. |
| doi_str_mv | 10.1023/b:caco.0000007984.79987.ec |
| format | Article |
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Thomas ; Evans, Alison A.</creator><creatorcontrib>Harris, Rebecca A. ; Chen, Gang ; Lin, Wen Yao ; Shen, Fu Min ; London, W. Thomas ; Evans, Alison A.</creatorcontrib><description>Chronic hepatitis B virus (HBV) carriers with high-titer viremia ($>10^{5}$ virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a prospective cohort of 114 adults from Haimen City, China, all HBV DNA(+) at study entry and followed for 797.8 person-years in total. During follow-up, 54 (47.4%) subjects spontaneously cleared high-titer viremia at least once. Of these, 27 were considered to have undergone stable seroconversion, 16 were considered unstable (12 reversions to HBV DNA positivity and 4 multiple clearances), and 11 did not have sufficient follow-up to determine stability. Of the 114 persons, 26 (22.8%) died during follow-up, 21 (18.4%) from HCC. Using Cox proportional hazards models, the RR of HCC death associated with seroconversion was 2.8 (95% CI = 1.1-7.4), controlling for age, sex, family HCC history, history of acute hepatitis, alcohol use and cigarette smoking. In conclusion, fluctuations of high-titer viremia may indicate increased hepatocellular damage and at least short-term increases in HCC risk. Long-term longitudinal studies are needed to clarify this relationship and its potential usefulness as a prognostic marker in chronic HBV infection.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1023/b:caco.0000007984.79987.ec</identifier><identifier>PMID: 14750539</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Netherlands: Kluwer Academic Publishers</publisher><subject>Adult ; Aged ; Antigens ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - virology ; Carrier State - virology ; Case-Control Studies ; China - epidemiology ; Cohort Studies ; Demographics ; DNA ; DNA damage ; DNA, Viral - analysis ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis ; Hepatitis antigens ; Hepatitis B ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - complications ; Hepatocellular carcinoma ; Humans ; Infections ; Liver cancer ; Liver Neoplasms - epidemiology ; Liver Neoplasms - virology ; Longitudinal studies ; Male ; Middle Aged ; Mortality ; Polymerase Chain Reaction ; Population ; Predisposing factors ; Proportional Hazards Models ; Risk factors ; Taq Polymerase ; Viral Load ; Viremia - complications ; Viremia - virology</subject><ispartof>Cancer causes & control, 2003-12, Vol.14 (10), p.995-1000</ispartof><rights>Copyright 2003 Kluwer Academic Publishers</rights><rights>Copyright Kluwer Academic Publishers Dec 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-fd6d2db3bf852201dc64b5810294d9f7d3dde256cae7622a24481b889dc6f4423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3554007$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3554007$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14750539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, Rebecca A.</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>Lin, Wen Yao</creatorcontrib><creatorcontrib>Shen, Fu Min</creatorcontrib><creatorcontrib>London, W. Thomas</creatorcontrib><creatorcontrib>Evans, Alison A.</creatorcontrib><title>Spontaneous Clearance of High-Titer Serum HBV DNA and Risk of Hepatocellular Carcinoma in a Chinese Population</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><description>Chronic hepatitis B virus (HBV) carriers with high-titer viremia ($>10^{5}$ virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a prospective cohort of 114 adults from Haimen City, China, all HBV DNA(+) at study entry and followed for 797.8 person-years in total. During follow-up, 54 (47.4%) subjects spontaneously cleared high-titer viremia at least once. Of these, 27 were considered to have undergone stable seroconversion, 16 were considered unstable (12 reversions to HBV DNA positivity and 4 multiple clearances), and 11 did not have sufficient follow-up to determine stability. Of the 114 persons, 26 (22.8%) died during follow-up, 21 (18.4%) from HCC. Using Cox proportional hazards models, the RR of HCC death associated with seroconversion was 2.8 (95% CI = 1.1-7.4), controlling for age, sex, family HCC history, history of acute hepatitis, alcohol use and cigarette smoking. In conclusion, fluctuations of high-titer viremia may indicate increased hepatocellular damage and at least short-term increases in HCC risk. Long-term longitudinal studies are needed to clarify this relationship and its potential usefulness as a prognostic marker in chronic HBV infection.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Carrier State - virology</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>Demographics</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA, Viral - analysis</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Hepatitis antigens</subject><subject>Hepatitis B</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Infections</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - virology</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Polymerase Chain Reaction</subject><subject>Population</subject><subject>Predisposing factors</subject><subject>Proportional Hazards Models</subject><subject>Risk factors</subject><subject>Taq Polymerase</subject><subject>Viral Load</subject><subject>Viremia - complications</subject><subject>Viremia - virology</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkctu1DAUhi0EotPCGyBkdcEug69x3N00XAapoogWtpZjO9RDYqd2suDt686MqMSGszmL853Lf34AzjFaY0To--7CaBPXaB9CNmwtpGzE2plnYIW5oJUghD8HKyS5qDhh9ASc5rwrNK8JeglOMBMccSpXINxMMcw6uLhk2A5OJx2Mg7GHW__rrrr1s0vwxqVlhNvLn_DD1w3UwcLvPv_eQ27SczRuGJZBJ9jqZHyIo4Y-QA3bOx9cdvBbnEp59jG8Ai96PWT3-pjPwI9PH2_bbXV1_flLu7mqDKvRXPW2tsR2tOsbTgjC1tSs401RL5mVvbDUWkd4bbQTNSGaMNbgrmlkAXvGCD0D7w5zpxTvF5dnNfr8eOZBqRKYE85q-V8QS1LThvMCnv8D7uKSQhGhCKblmbVoCnRxgEyKOSfXqyn5Uac_CiP16J26VO2mvVZP3qm9d8qZ0vz2uGHpRmefWo9mFeDNAdjlOaa_dco5K7PoA-Iwnu4</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Harris, Rebecca A.</creator><creator>Chen, Gang</creator><creator>Lin, Wen Yao</creator><creator>Shen, Fu Min</creator><creator>London, W. Thomas</creator><creator>Evans, Alison A.</creator><general>Kluwer Academic Publishers</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7U9</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Spontaneous Clearance of High-Titer Serum HBV DNA and Risk of Hepatocellular Carcinoma in a Chinese Population</title><author>Harris, Rebecca A. ; Chen, Gang ; Lin, Wen Yao ; Shen, Fu Min ; London, W. Thomas ; Evans, Alison A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-fd6d2db3bf852201dc64b5810294d9f7d3dde256cae7622a24481b889dc6f4423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Carrier State - virology</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>Demographics</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA, Viral - analysis</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Hepatitis antigens</topic><topic>Hepatitis B</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Infections</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - virology</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Polymerase Chain Reaction</topic><topic>Population</topic><topic>Predisposing factors</topic><topic>Proportional Hazards Models</topic><topic>Risk factors</topic><topic>Taq Polymerase</topic><topic>Viral Load</topic><topic>Viremia - complications</topic><topic>Viremia - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, Rebecca A.</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>Lin, Wen Yao</creatorcontrib><creatorcontrib>Shen, Fu Min</creatorcontrib><creatorcontrib>London, W. 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Thomas</au><au>Evans, Alison A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous Clearance of High-Titer Serum HBV DNA and Risk of Hepatocellular Carcinoma in a Chinese Population</atitle><jtitle>Cancer causes & control</jtitle><addtitle>Cancer Causes Control</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>14</volume><issue>10</issue><spage>995</spage><epage>1000</epage><pages>995-1000</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Chronic hepatitis B virus (HBV) carriers with high-titer viremia ($>10^{5}$ virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a prospective cohort of 114 adults from Haimen City, China, all HBV DNA(+) at study entry and followed for 797.8 person-years in total. During follow-up, 54 (47.4%) subjects spontaneously cleared high-titer viremia at least once. Of these, 27 were considered to have undergone stable seroconversion, 16 were considered unstable (12 reversions to HBV DNA positivity and 4 multiple clearances), and 11 did not have sufficient follow-up to determine stability. Of the 114 persons, 26 (22.8%) died during follow-up, 21 (18.4%) from HCC. Using Cox proportional hazards models, the RR of HCC death associated with seroconversion was 2.8 (95% CI = 1.1-7.4), controlling for age, sex, family HCC history, history of acute hepatitis, alcohol use and cigarette smoking. In conclusion, fluctuations of high-titer viremia may indicate increased hepatocellular damage and at least short-term increases in HCC risk. Long-term longitudinal studies are needed to clarify this relationship and its potential usefulness as a prognostic marker in chronic HBV infection.</abstract><cop>Netherlands</cop><pub>Kluwer Academic Publishers</pub><pmid>14750539</pmid><doi>10.1023/b:caco.0000007984.79987.ec</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Antigens Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - virology Carrier State - virology Case-Control Studies China - epidemiology Cohort Studies Demographics DNA DNA damage DNA, Viral - analysis Enzyme-Linked Immunosorbent Assay Female Hepatitis Hepatitis antigens Hepatitis B Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - complications Hepatocellular carcinoma Humans Infections Liver cancer Liver Neoplasms - epidemiology Liver Neoplasms - virology Longitudinal studies Male Middle Aged Mortality Polymerase Chain Reaction Population Predisposing factors Proportional Hazards Models Risk factors Taq Polymerase Viral Load Viremia - complications Viremia - virology |
| title | Spontaneous Clearance of High-Titer Serum HBV DNA and Risk of Hepatocellular Carcinoma in a Chinese Population |
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