Spontaneous Clearance of High-Titer Serum HBV DNA and Risk of Hepatocellular Carcinoma in a Chinese Population

Chronic hepatitis B virus (HBV) carriers with high-titer viremia ($>10^{5}$ virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a...

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Veröffentlicht in:Cancer causes & control 2003-12, Vol.14 (10), p.995-1000
Hauptverfasser: Harris, Rebecca A., Chen, Gang, Lin, Wen Yao, Shen, Fu Min, London, W. Thomas, Evans, Alison A.
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Sprache:eng
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Zusammenfassung:Chronic hepatitis B virus (HBV) carriers with high-titer viremia ($>10^{5}$ virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a prospective cohort of 114 adults from Haimen City, China, all HBV DNA(+) at study entry and followed for 797.8 person-years in total. During follow-up, 54 (47.4%) subjects spontaneously cleared high-titer viremia at least once. Of these, 27 were considered to have undergone stable seroconversion, 16 were considered unstable (12 reversions to HBV DNA positivity and 4 multiple clearances), and 11 did not have sufficient follow-up to determine stability. Of the 114 persons, 26 (22.8%) died during follow-up, 21 (18.4%) from HCC. Using Cox proportional hazards models, the RR of HCC death associated with seroconversion was 2.8 (95% CI = 1.1-7.4), controlling for age, sex, family HCC history, history of acute hepatitis, alcohol use and cigarette smoking. In conclusion, fluctuations of high-titer viremia may indicate increased hepatocellular damage and at least short-term increases in HCC risk. Long-term longitudinal studies are needed to clarify this relationship and its potential usefulness as a prognostic marker in chronic HBV infection.
ISSN:0957-5243
1573-7225
DOI:10.1023/b:caco.0000007984.79987.ec