RNAi: nature abhors a double-strand

RNAi: nature abhors a double-strand

In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclea...

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Veröffentlicht in:Current Opinion in Genetics & Development 2002-04, Vol.12 (2), p.225-232
Hauptverfasser: Hutvágner, György, Zamore, Phillip D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
double-stranded RNA
Endoribonucleases - physiology
Nematoda
post-transcriptional gene silencing
PTGS
Ribonuclease III
RNA interference
RNA Replicase - physiology
RNA, Double-Stranded - physiology
RNA, Messenger - metabolism
RNAi
siRNA
small interfering RNA
small temporal RNA
stRNA
Trypanosoma
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Beschreibung
Zusammenfassung:In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(02)00290-3