Anti-Inflammatory Compounds of Plant Origin. Part I. Action on Arachidonic Acid Pathway, Nitric Oxide and Nuclear Factor κ B (NF-κB)

Abstract Over the last 10 years, a significant body of evidence has emerged indicating that chemically diverse classes of naturally-occurring substances derived from higher plants are of potential interest for therapeutic interventions in several inflammatory diseases. Part I of this review article...

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Veröffentlicht in:Planta medica 2003-11, Vol.69 (11), p.973-983
Hauptverfasser: Calixto, João B., Otuki, Michel F., Santos, Adair R.S.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Over the last 10 years, a significant body of evidence has emerged indicating that chemically diverse classes of naturally-occurring substances derived from higher plants are of potential interest for therapeutic interventions in several inflammatory diseases. Part I of this review article focuses on our current knowledge of the mechanisms by which a large range of plant-derived constituents interfere with three relevant targets involved in the inflammatory process, namely arachidonic acid metabolite pathways, nitric oxide and NF-κB, and discusses their potential therapeutic use in the management of relevant inflammatory diseases.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2003-45141