Stereoselective syntheses of (±)-epibatidine analogues

Stereoselective syntheses of (±)-epibatidine analogues2, which contain the 8-azabicyclo [3.2.1]octane ring system, were achieved by using palladium-catalyzed cross-coupling reaction from4 and the analgesic activity was tested by Mouse writhing antinociceptive assay.

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Bibliographische Detailangaben
Veröffentlicht in:	Archives of pharmacal research 2002-02, Vol.25 (1), p.45-48
Hauptverfasser:	Kim, Yong-Hyun, Won, Do-Youn, Oh, Chang-Young, Lee, Kee-Young, Lee, Yiu-Suk, Woo, Nam-Tae, Park, Young-Ho, Park, Hyun-Ju, Ham, Won-Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	analgesic effect Analgesics, Non-Narcotic - chemical synthesis Analgesics, Non-Narcotic - chemistry Animals Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Catalysis Indicators and Reagents Magnetic Resonance Spectroscopy Male Mice Mice, Inbred ICR Nicotinic Agonists - chemical synthesis Nicotinic Agonists - chemistry octane Pain Measurement - drug effects Pyridines - chemical synthesis Pyridines - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	Stereoselective syntheses of (±)-epibatidine analogues2, which contain the 8-azabicyclo [3.2.1]octane ring system, were achieved by using palladium-catalyzed cross-coupling reaction from4 and the analgesic activity was tested by Mouse writhing antinociceptive assay.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/BF02975259